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1. WO2007142923 - MIF INHIBITORS FOR TREATING NEUROPATHIC PAIN AND ASSOCIATED SYNDROMES

Publication Number WO/2007/142923
Publication Date 13.12.2007
International Application No. PCT/US2007/012655
International Filing Date 29.05.2007
IPC
A61K 31/496 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61P 25/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
Applicants
  • AVIGEN, INC. [US]/[US] (AllExceptUS)
  • GAETA, Federico [US]/[US] (UsOnly)
Inventors
  • GAETA, Federico
Agents
  • ROBINS, Roberta
Priority Data
60/810,03431.05.2006US
60/812,33808.06.2006US
60/873,67107.12.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MIF INHIBITORS FOR TREATING NEUROPATHIC PAIN AND ASSOCIATED SYNDROMES
(FR) INHIBITEURS MIF DESTINÉS AU TRAITEMENT D'UNE DOULEUR NÉVROPATHIQUE ET DES SYNDROMES ASSOCIÉS
Abstract
(EN)
Methods of using MIF inhibitors such as those characterized by structure I are disclosed. The MIF inhibitors can be used for treating conditions such as neuropathic pain and its associated symptoms, as well as for treating drug and behavioral addictions, such as opiate dependence. Additionally, MIF inhibitor compounds can be used for treating withdrawal syndromes after discontinuance of addictive drug use or behavior.
(FR)
La présente invention concerne des procédés d'utilisation d'inhibiteurs du facteur inhibiteur de la migration des macrophages (MIF) tels que les composés caractérisés par la structure I. Les inhibiteurs MIF peuvent être utilisés pour le traitement de pathologies telles qu'une douleur névropathique et des symptômes associés, ainsi que pour le traitement de toxicomanies et de penchants malsains, tels que l'accoutumance aux substances opiacées. De plus, les composés d'inhibiteurs MIF peuvent être utilisés pour le traitement des syndromes d'état de manque dûs à l'arrêt de la consommation de substances toxicomanogènes ou de penchants malsains.
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