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1. WO2007141502 - CHEMICAL COMPOUNDS

Publication Number WO/2007/141502
Publication Date 13.12.2007
International Application No. PCT/GB2007/002048
International Filing Date 04.06.2007
IPC
C07D 263/48 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
30having two or three double bonds between ring members or between ring members and non-ring members
34with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48Nitrogen atoms not forming part of a nitro radical
A61K 31/421 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
4211,3-Oxazoles, e.g. pemoline, trimethadione
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
CPC
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 263/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
30having two or three double bonds between ring members or between ring members and non-ring members
34with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48Nitrogen atoms not forming part of a nitro radical
Applicants
  • ASTRAZENECA AB [SE]/[SE] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • ASTRAZENECA UK LIMITED [GB]/[GB] (MG)
  • BUTLIN, Roger, John [GB]/[GB] (UsOnly)
  • DAVIES, Robert [GB]/[GB] (UsOnly)
  • MCCOULL, William [GB]/[GB] (UsOnly)
Inventors
  • BUTLIN, Roger, John
  • DAVIES, Robert
  • MCCOULL, William
Agents
  • GLOBAL INTELLECTUAL PROPERTY
Priority Data
60/811,37506.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHEMICAL COMPOUNDS
(FR) COMPOSÉS CHIMIQUES
Abstract
(EN)
Compounds of formula (I), or salts thereof, which inhibit acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, (A chemical formula should be inserted here - please see paper copy enclosed herewith) (I) wherein, for example, R1 is an optionally substituted aryl or optionally substituted heteroaryl group, Y is a direct bond, or a defined linking group and R2 is an optionally substituted aryl, an optionally substituted cycloalkyl or an optionally substituted heterocyclic group; together with processes for their preparation, pharmaceutical compositions containing them and their use as medicaments.
(FR)
L'invention concerne des composés de formule (I) ou leurs sels, qui inhibent l'activité de l'acétyle CoA(acétyle coenzyme A) : diacylglycérol acyltransférase (DGAT1) (A chemical formula should be inserted here - please see paper copy enclosed herewith) (I) dans laquelle par exemple R1 est un groupement aryle éventuellement substitué ou hétéroaryle éventuellement substitué, Y est une liaison directe ou un groupe de liaison défini et R2 est un groupement aryle éventuellement substitué, cycloalkyle éventuellement substitué ou hétérocyclique éventuellement substitué ; ainsi que des procédés de préparation de ces composés, des compositions pharmaceutiques les contenant et leur utilisation en tant que médicaments.
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