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1. WO2007141005 - USE OF GLUTAMYL AMINOPEPTIDASE (ENPEP) AS A THERAPEUTIC OR DIAGNOSTIC TARGET

Publication Number WO/2007/141005
Publication Date 13.12.2007
International Application No. PCT/EP2007/005013
International Filing Date 06.06.2007
IPC
G01N 33/573 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
573for enzymes or isoenzymes
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
C12Q 1/37
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
34involving hydrolase
37involving peptidase or proteinase
G01N 33/573
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
573for enzymes or isoenzymes
G01N 33/57438
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57438of liver, pancreas or kidney
Applicants
  • BAYER HEALTHCARE AG [DE]/[DE] (AllExceptUS)
  • GOLZ, Stefan [DE]/[DE] (UsOnly)
  • BRÜGGEMEIER, Ulf [DE]/[DE] (UsOnly)
  • GEERTS, Andreas [DE]/[DE] (UsOnly)
Inventors
  • GOLZ, Stefan
  • BRÜGGEMEIER, Ulf
  • GEERTS, Andreas
Common Representative
  • BAYER HEALTHCARE AG
Priority Data
06011908.809.06.2006EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF GLUTAMYL AMINOPEPTIDASE (ENPEP) AS A THERAPEUTIC OR DIAGNOSTIC TARGET
(FR) UTILISATION DE GLUTAMYL AMINOPEPTIDASE (ENPEP) COMME CIBLE THÉRAPEUTIQUE OU DIAGNOSTIQUE
Abstract
(EN)
The invention provides a human ENEP which is associated with the cardiovascular diseases, hematological diseases, urological diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, urological diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of ENEP as well as pharmaceutical compositions comprising such compounds.
(FR)
L'invention concerne une ENPEP humaine qui est associée aux maladies cardiovasculaires, hématologiques, urologiques et au cancer. L'invention concerne également des essais destinés à l'identification de composés utiles pour le traitement ou la prévention de maladies cardiovasculaires, hématologiques, urologiques et du cancer. L'invention porte également sur des composés qui se lient à l'ENPEP et/ou l'activent ou inhibent son activité ainsi que sur des compositions pharmaceutiques contenant lesdits composés.
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