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1. WO2007140611 - SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE

Publication Number WO/2007/140611
Publication Date 13.12.2007
International Application No. PCT/CA2007/001008
International Filing Date 06.06.2007
IPC
C07C 219/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
219Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
02having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
14having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
A61K 31/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
235having an aromatic ring attached to a carboxyl group
24having an amino or nitro group
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07C 213/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
08by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
C07C 327/48 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
38Amides of thiocarboxylic acids
48having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
C07D 339/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
339Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
02Five-membered rings
04having the hetero atoms in positions 1 and 2, e.g. lipoic acid
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07C 219/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
219Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
02having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
20the carbon skeleton being unsaturated
22and containing six-membered aromatic rings
Applicants
  • ANTIBE THERAPEUTICS INC. [CA]/[CA] (AllExceptUS)
  • WALLACE, John, L. [CA]/[CA] (UsOnly)
  • CIRINO, Giuseppe [IT]/[IT] (UsOnly)
  • SANTAGADA, Vincenzo [IT]/[IT] (UsOnly)
  • CALIENDO, Giuseppe [IT]/[IT] (UsOnly)
Inventors
  • WALLACE, John, L.
  • CIRINO, Giuseppe
  • SANTAGADA, Vincenzo
  • CALIENDO, Giuseppe
Agents
  • BENNETT JONES LLP
Priority Data
60/804,06706.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE
(FR) SELS DE TRIMÉBUTINE ET DE N-DÉMÉTHYLTRIMÉBUTINE
Abstract
(EN)
Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are particularly useful in the treatment of conditions characterized by abdominal pain, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), diabetic gastroparesis, and dyspepsia.
(FR)
La présente invention concerne des sels spécifiques de trimébutine et de N-monodéméthyltrimébutine, ainsi que leurs stéréoisomères correspondants, lesdits composés présentant des propriétés analgésiques améliorées utiles dans le traitement de la douleur viscérale. Les sels selon la présente invention sont particulièrement utiles dans le traitement d'états pathologiques caractérisés par une douleur abdominale, par exemple l'affection abdominale inflammatoire (AAI) et le syndrome du côlon irritable (SCI), la gastroparésie diabétique et la dyspepsie.
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