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1. WO2007140312 - ANTI-CROSS-LINKING AGENTS AND METHODS FOR INHIBITING CROSS-LINKING OF INJECTABLE HYDROGEL FORMULATIONS

Publication Number WO/2007/140312
Publication Date 06.12.2007
International Application No. PCT/US2007/069766
International Filing Date 25.05.2007
Chapter 2 Demand Filed 11.02.2008
IPC
B01D 21/01 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
21Separation of suspended solid particles from liquids by sedimentation
01using flocculating agents
B01D 43/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
43Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
C09K 3/00 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
KMATERIALS FOR APPLICATIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
3Materials not provided for elsewhere
B01F 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
3Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed
B01F 17/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
17Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
B01J 13/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
CPC
A61K 47/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers ; , poly(meth)acrylates, or polyvinyl pyrrolidone
A61K 9/0024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
C08F 2810/20
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
2810Chemical modification of a polymer
20leading to a crosslinking, either explicitly or inherently
C08F 8/00
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
8Chemical modification by after-treatment
C08J 3/075
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
3Processes of treating or compounding macromolecular substances
02Making solutions, dispersions or lattices by other methods than by solution, emulsion or suspension polymerisation techniques
03in aqueous media
075Macromolecular gels
C08J 3/28
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
3Processes of treating or compounding macromolecular substances
28Treatment by wave energy or particle radiation
Applicants
  • THE GENERAL HOSPITAL CORPORATION [US]/[US] (AllExceptUS)
  • MURATOGLU, Orhun, K. [US]/[US] (UsOnly)
  • ORAL, Ebru [TR]/[US] (UsOnly)
  • BODUGOZ-SENTURK, Hatice [TR]/[US] (UsOnly)
Inventors
  • MURATOGLU, Orhun, K.
  • ORAL, Ebru
  • BODUGOZ-SENTURK, Hatice
Agents
  • ISACSON, John, P.
Priority Data
60/803,17725.05.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-CROSS-LINKING AGENTS AND METHODS FOR INHIBITING CROSS-LINKING OF INJECTABLE HYDROGEL FORMULATIONS
(FR) AGENTS ANTI-RÉTICULATION ET PROCÉDÉS PERMETTANT DE BLOQUER LA RÉTICULATION DE PRÉPARATIONS D'HYDROGEL INJECTABLES
Abstract
(EN)
The invention relates to cross-link-resistant injectable hydrogel formulations and methods of partially or practically wholly inhibiting injectable hydrogel formulations from cross-linking during irradiation using anti-cross-linking agents, which facilitates injectability of the hydrogel formulation. The invention also relates to methods of making the cross-link-resistant, for example, irradiation cross-link resistant, injectable hydrogel formulations, and methods of administering the same in treating a subject in need.
(FR)
Cette invention concerne des préparations d'hydrogel injectables résistantes à la réticulation, ainsi que des procédés permettant de bloquer en partie ou totalement la réticulation des préparations d'hydrogel injectables pendant le rayonnement au moyen d'agents anti-réticulation, ce qui améliore l'injectabilité de la préparation d'hydrogel. Cette invention concerne également des procédés permettant de conférer aux préparations d'hydrogel injectables une résistance à la réticulation, par exemple, une résistance à la réticulation par rayonnement, ainsi que des méthodes d'administration de ces préparations pour traiter un sujet qui le nécessite.
Also published as
EP2007784150
Other related publications
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