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1. WO2007140212 - TARTRATE SALT OF ISOFAGOMINE AND METHODS OF USE

Publication Number WO/2007/140212
Publication Date 06.12.2007
International Application No. PCT/US2007/069550
International Filing Date 23.05.2007
IPC
C07D 211/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
40Oxygen atoms
44attached in position 4
46having a hydrogen atom as the second substituent in position 4
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 211/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
40Oxygen atoms
44attached in position 4
46having a hydrogen atom as the second substituent in position 4
Applicants
  • AMICUS THERAPEUTICS, INC. [US]/[US] (AllExceptUS)
  • MUGRAGE, Benjamin [US]/[US] (UsOnly)
  • SHETH, Kamlesh, A. [US]/[US] (UsOnly)
  • PALLING, David [US]/[US] (UsOnly)
  • RYBCZYNSKI, Philip, J. [US]/[US] (UsOnly)
Inventors
  • MUGRAGE, Benjamin
  • SHETH, Kamlesh, A.
  • PALLING, David
  • RYBCZYNSKI, Philip, J.
Agents
  • CHANG, Sik Kim
Priority Data
60/808,02024.05.2006US
60/890,71920.02.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TARTRATE SALT OF ISOFAGOMINE AND METHODS OF USE
(FR) SEL DE TARTRATE D'ISOFAGOMINE ET SES MÉTHODES D'UTILISATION
Abstract
(EN)
A novel tartaric acid salt of Isofagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition containing the salt, and a method of treating Gaucher disease.
(FR)
L'invention concerne un nouveau sel d'acide tartrique d'isofagomine (tartrate d'isofagomine) pouvant être utilisé pour traiter la maladie de Gaucher. L'invention concerne également une forme cristalline de tartrate d'isofagomine, un procédé de préparation de ce sel, une composition pharmaceutique contenant ledit sel et une méthode de traitement de la maladie de Gaucher.
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