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1. WO2007139914 - COLLAGEN MIMICS

Publication Number WO/2007/139914
Publication Date 06.12.2007
International Application No. PCT/US2007/012451
International Filing Date 25.05.2007
IPC
C07K 14/78 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
C07K 5/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
CPC
C07K 14/001
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
001by chemical synthesis
C07K 14/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
C07K 5/0821
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0821with the first amino acid being heterocyclic, e.g. His, Pro, Trp
Applicants
  • WISCONSIN ALUMNI RESEARCH FOUNDATION [US]/[US] (AllExceptUS)
  • RAINES, Ronald, T. [US]/[US] (UsOnly)
  • SHOULDERS, Matthew, D. [US]/[US] (UsOnly)
  • HODGES, Jonathan, A. [US]/[US] (UsOnly)
Inventors
  • RAINES, Ronald, T.
  • SHOULDERS, Matthew, D.
  • HODGES, Jonathan, A.
Agents
  • VINAROV, Sara, D.
Priority Data
60/808,74526.05.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COLLAGEN MIMICS
(FR) MIMÉTIQUES DE COLLAGÈNE
Abstract
(EN)
Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-GIy)n, where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.
(FR)
La présente invention concerne de nouveaux mimétiques de collagène avec un motif tripeptidique de formule (Xaa-Yaa-GIy)n, où une des positions de Xaa ou Yaa est un dérivé de proline massif non extracteur d'électrons. Grâce à la substitution d'un dérivé de proline à la position Xaa ou Yaa dans l'hélice de collagène natif, la stabilité de l'hélice est accrue due uniquement aux effets stériques par rapport aux hélices triples associés au collagène connus. L'invention concerne également des procédés de fabrication de nouveaux mimétiques de collagène.
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