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1. WO2007139661 - XYLITOL TROCHES AND METHODS OF USE

Publication Number WO/2007/139661
Publication Date 06.12.2007
International Application No. PCT/US2007/010967
International Filing Date 04.05.2007
IPC
A61K 9/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
22Sustained or differential release type
24Layered or laminated unitary dosage forms
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
CPC
A61K 9/0056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
A61K 9/006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2086
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2072characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
Applicants
  • HALEY, Jeffrey, T. [US]/[US]
  • EDWARDS, Steven [US]/[US] (UsOnly)
Inventors
  • HALEY, Jeffrey, T.
  • EDWARDS, Steven
Agents
  • KING, Joshua
Priority Data
60/808,03523.05.2006US
60/879,84611.01.2007US
60/887,59522.02.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) XYLITOL TROCHES AND METHODS OF USE
(FR) TROCHISQUES À BASE DE XILITOL ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN)
A slow-dissolving troche with polyol molecules is disclosed. It may be an adherent troche, preferably adhered to teeth or gums or cheek with acacia gum, or a lollipop or child's pacifier. Consumers are instructed to use the troches at the end of each day and after each meal, at least four times per day to benefit oral health, particularly caries, gingivitis, periodontitis, ear infections, sinus infections, halitosis and risk of Streptococcus mutans infecting their blood from their mouths. The polyol molecules are preferably xylitol. The troches may be made with a bi-layer tablet press rounded on one side and flat on the other, preferably using acacia gum in the flat side layer for adhesion.
(FR)
La présente invention concerne un trochisque à dissolution lente contenant des molécules de polyol. Le trochisque peut être adhérent, adhérant de préférence aux dents ou aux gencives ou à la joue avec une gomme d'acacia, ou une sucette ou une tétine. Des instructions sont prévues pour indiquer au consommateurs la manière d'utiliser les trochisques à la fin de chaque jour et après chaque repas, au moins quatre fois par jour pour bénéficier d'une santé buccale, notamment concernant la carie dentaire, la gingivite, la parodontose, les infections de l'oreille, les infections du sinus, la mauvaise haleine et le risque d'infection de Streptococcus mutans dérivé du sang provenant de leurs bouches. Le molécules de polyol sont de préférence à base de xylitol. Les trochisques peuvent être produits avec un comprimé bicouche arrondi d'un côté et plat de l'autre, avec de préférence la gomme d'acacia sur la couche côté plat pour l'adhésion.
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