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1. WO2007139192 - OPTICAL MEASURING DEVICE, OPTICAL MEASURING METHOD, AND STORAGE MEDIUM STORING OPTICAL MEASUREMENT PROGRAM

Publication Number WO/2007/139192
Publication Date 06.12.2007
International Application No. PCT/JP2007/061108
International Filing Date 31.05.2007
Chapter 2 Demand Filed 28.03.2008
IPC
A61B 5/1455 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
1455using optical sensors, e.g. spectral photometrical oximeters
G01N 21/35 2014.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
35using infra-red light
G01N 21/359 2014.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
35using infra-red light
359using near infra-red light
CPC
A61B 5/0059
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
A61B 5/14532
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
14532for measuring glucose, e.g. by tissue impedance measurement
A61B 5/14551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
1455using optical sensors, e.g. spectral photometrical oximeters
14551for measuring blood gases
G01N 2021/3144
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
314with comparison of measurements at specific and non-specific wavelengths
3144for oxymetry
G01N 2021/4797
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
47Scattering, i.e. diffuse reflection
4795spatially resolved investigating of object in scattering medium
4797time resolved, e.g. analysis of ballistic photons
G01N 21/31
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
Applicants
  • 国立大学法人静岡大学 NATIONAL UNIVERSITY CORPORATION SHIZUOKA UNIVERSITY [JP]/[JP] (AllExceptUS)
  • 庭山 雅嗣 NIWAYAMA, Masatsugu [JP]/[JP] (UsOnly)
Inventors
  • 庭山 雅嗣 NIWAYAMA, Masatsugu
Agents
  • 中島 淳 NAKAJIMA, Jun
Priority Data
2006-15217731.05.2006JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) OPTICAL MEASURING DEVICE, OPTICAL MEASURING METHOD, AND STORAGE MEDIUM STORING OPTICAL MEASUREMENT PROGRAM
(FR) dispositif de mesure OPTIQUE, procÉdÉ DE MESURE OPTIQUE, et support de stockage de PROGRAMME de mesure optique
(JA) 光学的測定装置、光学的測定方法、及び光学的測定プログラムを格納した記憶媒体
Abstract
(EN)
An optical measuring device and method for accurately measuring light absorbance of a deep layer tissue of a human body or a piece of fruit by correcting the adverse influence of the superficial layer and a storage medium storing an optical measurement program are disclosed. The optical measuring device has a probe composed of a light-emitting diode and two photodiodes. Light emitted from the light-emitting diode and passing through the superficial layer and the deep layer of a tissue is received by one of the photodiode, and light emitted from the light-emitting diode and passing through the superficial and deep layers of the tissue and traveling a distance in the deep layer different from the distance which the light received by the one photodiode travels is received by the other photodiode. A control unit computes the propagation coefficient in the medium where the light propagates from the intensities of the lights received by the photodiodes. An arithmetic expression is selected depending on the inputted thickness of the fat of the tissue, and the light absorbance coefficient of the muscle tissue is determined by the arithmetic expression according to the fat thickness and the spatial inclination. From the determined light absorbance coefficient, the hemoglobin concentration and the degree of oxygen saturation are determined.
(FR)
L'invention concerne un dispositif de mesure optique et un procédé permettant de mesurer avec précision l'absorbance de lumière d'un tissu de couche profonde du corps humain ou d'un fruit en corrigeant l'influence négative de la couche superficielle, et un support de stockage de programme de mesure optique. Le dispositif de mesure optique possède une sonde composée d'une diode électroluminescente et de deux photodiodes. La lumière émise de la diode électroluminescente et passant à travers la couche superficielle et la couche profonde d'un tissu est reçue par l'une des photodiodes, et la lumière émise de la diode électroluminescente et passant à travers la couche superficielle et la couche profonde du tissu et parcourant une distance dans la couche profonde différente de la distance parcourue par la lumière reçue par ladite photodiode, est reçue par l'autre photodiode. Une unité de commande calcule le coefficient de propagation dans le support dans lequel la lumière se propage à partir des intensités des lumières reçues par les photodiodes. Une expression arithmétique est sélectionnée en fonction de l'épaisseur saisie de la graisse du tissu, et le coefficient d'absorbance de lumière du tissu musculaire est déterminé par l'expression arithmétique selon l'épaisseur de graisse et l'inclinaison spatiale. À partir du coefficient d'absorbance de lumière déterminé, on évalue la concentration en hémoglobine et le degré de saturation d'oxygène.
(JA)
 浅層組織の影響などを補正して人体や果物等の深層組織の光の吸収度合いを正確に測定可能な光学的測定装置、光学的測定方法、及び光学的測定プログラムを格納した記憶媒体が開示される。光学的測定装置は、1つの発光ダイオードと2つのフォトダイオードを備えたプローブを有し、以下のように構成される。発光ダイオードからの光のうち組織の浅層及び深層を通過した光が一方のフォトダイオードで受光され、組織の浅層及び深層を通過した光であり前記一方のフォトダイオードでの検出光とは深層の通過距離の異なる光が他方のフォトダイードで受光される。制御部が、各フォトダイオードで受光した光の光強度に基づいて光が伝搬する媒体中の伝搬定数を算出する。入力された組織の脂肪厚に対応する演算式を選択して、脂肪厚及び空間的傾きに基き演算式により筋組織の光の吸収係数を求める。求めた光の吸収係数に基づいて、ヘモグロビン濃度や酸素飽和度を求める。
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