Processing

Please wait...

Settings

Settings

Goto Application

1. WO2007138933 - REMEDY FOR DIABETES

Publication Number WO/2007/138933
Publication Date 06.12.2007
International Application No. PCT/JP2007/060448
International Filing Date 22.05.2007
IPC
A61K 36/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
02Algae
A61K 31/336 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
A61K 31/737 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
A61P 3/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
A61K 31/737
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
A61K 36/03
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
02Algae
03Phaeophycota or phaeophyta (brown algae), e.g. Fucus
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • 株式会社エフ・シーシー堀内 FCC HORIUCHI CO., LTD. [JP]/[JP] (AllExceptUS)
  • 大石 一二三 OHISHI, Hifumi [JP]/[JP] (UsOnly)
  • 谷 久典 TANI, Hisanori [JP]/[JP] (UsOnly)
  • 服部 隆史 HATTORI, Takashi [JP]/[JP] (UsOnly)
  • 大石 哲也 OHISHI, Tetsuya [JP]/[JP] (UsOnly)
Inventors
  • 大石 一二三 OHISHI, Hifumi
  • 谷 久典 TANI, Hisanori
  • 服部 隆史 HATTORI, Takashi
  • 大石 哲也 OHISHI, Tetsuya
Agents
  • 社本 一夫 SHAMOTO, Ichio
Priority Data
2006-14485425.05.2006JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) REMEDY FOR DIABETES
(FR) REMÈDE CONTRE LE DIABÈTE
(JA) 糖尿病治療剤
Abstract
(EN)
It is intended to lower the blood retinol-binding protein level of an insulin-independent diabetic patient to the normal range. To facilitate the excretion of the retinol-binding protein from the kidney, a substance having a larger side chain than retinol is bonded to the retinol-binding protein to thereby inhibit the formation of a complex thereof with transthyretin. Use is made of a carotenoid fraction originating in a brown alga which can inhibit the formation of a complex of the retinol-binding protein with transthyretin. It is preferable that the carotenoid fraction comprises fucoxanthin and/or its analog. As the starting brown algae, use can be appropriately made of natural or farmed mozuku, in particular, Okinawa mozuku (Cladoshiphon okamuranus Tokida, Cladoshiphon novae-caledoniae Kylin or Cladoshiphon caledoniae Kylin).
(FR)
La présente invention concerne la réduction à un taux normal du niveau des protéines de liaison au rétinol sanguin chez un patient diabétique insulino-indépendant. Afin de faciliter l'excrétion rénale de la protéine de liaison au rétinol, une substance comportant une chaîne latérale plus longue que le rétinol est liée à la protéine de liaison au rétinol pour de ce fait inhiber la formation d'un complexe de ladite protéine avec la transthyrétine. L'invention concerne l'utilisation d'une fraction de caroténoïde provenant d'une algue brune capable d'inhiber la formation dudit complexe de la protéine de liaison au rétinol avec la transthyrétine. Il est préférable que la fraction de caroténoïde contienne de la fucoxanthine et/ou ses analogues. Comme source d'algues brunes, il est possible d'utiliser de manière adéquate l'algue mozuku, naturelle ou d'élevage, et en particulier, Okinawa mozuku (Cladoshiphon okamuranus Tokida, Cladoshiphon novae-caledoniae Kylin ou Cladoshiphon caledoniae Kylin).
(JA)
 インスリン非依存性糖尿病者の血中のレチノール結合蛋白質を正常域にまで低下させる。レチノール結合蛋白質を腎臓から容易に排泄させるために、レチノールよりも側鎖の大きい物質をレチノール結合蛋白質に結合させてトランスサイレチンとの複合体形成を阻害する。  褐藻類由来の、レチノール結合蛋白質とトランスサイレチンとの複合体形成の結合を阻害することができるカロチノイド画分を用いる。カロチノイド画分は、好ましくは、フコキサンチン及び/又はその類縁体からなる。原料褐藻類としては、天然又は養殖されたモズク、特にオキナワモズク(Cladoshiphon okamuranus Tokida)、Cladoshiphon novae-caledoniae Kylin)、又はCladoshiphon caledoniae Kylinを好適に用いることができる。  
Latest bibliographic data on file with the International Bureau