Processing

Please wait...

Settings

Settings

Goto Application

1. WO2007138574 - MONITORING RESPONSIVENESS TO AND SCREENING FOR THERAPEUTIC COMPOUNDS THAT MODULAT COMPOSITION AND STRUCTURE OF CELL MEMBRANES

Publication Number WO/2007/138574
Publication Date 06.12.2007
International Application No. PCT/IL2007/000633
International Filing Date 24.05.2007
IPC
A61K 31/7028 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
C12Q 1/02 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
G01N 33/5047
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5044involving specific cell types
5047Cells of the immune system
Applicants
  • HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. [IL]/[IL] (AllExceptUS)
  • ILAN, Yaron [IL]/[IL] (UsOnly)
Inventors
  • ILAN, Yaron
Agents
  • LUZZATTO, Kfir
Priority Data
17594525.05.2006IL
17882123.10.2006IL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONITORING RESPONSIVENESS TO AND SCREENING FOR THERAPEUTIC COMPOUNDS THAT MODULAT COMPOSITION AND STRUCTURE OF CELL MEMBRANES
(FR) MODULATION DIRECTE ET INDIRECTE DE LA COMPOSITION ET DE LA STRUCTURE DE MEMBRANES CELLULAIRES PAR UN COMPOSÉ THÉRAPEUTIQUE ET MÉTHODES D'UTILISATION DANS LE CADRE DE TECHNIQUES DE CONTRÔLE DE LA RÉACTIVITÉ ET DE PROCÉDÉS DE CRIBLAGE
Abstract
(EN)
The present invention relates to modulation of structure and composition of cell membranes by a given therapeutic compound, preferably, a β-glycolipid and thereby to modulation and treatment of pathologic disorders. More particularly, the invention relates to the use of modulation of structure and composition of immune cell membranes by a candidate therapeutic compound as a diagnostic marker for prediction and monitoring of response to treatment. The invention further provides a method of screening for substances which modulate the structure and composition of cell membranes, as well as compositions and methods using the substances identified by the screening method of the invention, for the treatment of pathologic disorders.
(FR)
Modulation de la structure et de la composition de membranes cellulaires au moyen d'un composé thérapeutique donné, de préférence un β-glycolipide, et donc modulation et traitement de troubles pathologiques. Plus précisément, l'invention concerne l'utilisation de la modulation de la structure et de la composition de membranes cellulaires immunitaires par un composé thérapeutique candidat en tant que marqueur diagnostique pour la prévision et la surveillance de la réponse à un traitement. De plus, l'invention concerne une méthode de criblage de substances modulant la structure et la composition de membranes cellulaires, ainsi que des compositions et des méthodes faisant intervenir les substances identifiées au moyen du procédé de criblage de l'invention en vue du traitement de troubles pathologiques.
Latest bibliographic data on file with the International Bureau