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1. WO2007138236 - SHEDDASE ENZYMES FOR NEURON GROWTH

Publication Number WO/2007/138236
Publication Date 06.12.2007
International Application No. PCT/GB2006/001904
International Filing Date 24.05.2006
IPC
A61K 38/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 38/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
A61K 38/1825
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
1825Fibroblast growth factor [FGF]
A61K 38/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
A61K 38/4886
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
4886Metalloendopeptidases (3.4.24), e.g. collagenase
C12Y 304/24081
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
304Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
24Metalloendopeptidases (3.4.24)
24081ADAM10 endopeptidase (3.4.24.81)
C12Y 304/24086
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
304Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
24Metalloendopeptidases (3.4.24)
24086ADAM 17 endopeptidase (3.4.24.86), i.e. TNF-alpha converting enyzme
Applicants
  • THE UNIVERSITY OF BIRMINGHAM [GB]/[GB] (AllExceptUS)
  • LOGAN, Ann [GB]/[GB] (UsOnly)
  • BERRY, Martin [GB]/[GB] (UsOnly)
  • AHMED, Zubair [GB]/[GB] (UsOnly)
Inventors
  • LOGAN, Ann
  • BERRY, Martin
  • AHMED, Zubair
Agents
  • WARD, David, I.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SHEDDASE ENZYMES FOR NEURON GROWTH
(FR) ENZYMES DE TYPE SHEDDASE POUR LA CROISSANCE DES NEURONES
Abstract
(EN)
The invention provides a method of promoting axon and/or or neurite branching and/or outgrowth and/or for inhibiting cell apoptosis in a subject, the method comprising administering to a subject in need of such treatment a composition comprising a sheddase enzyme, or analogue, or derivative, or activator thereof. The invention also provides a delivery system for use in a gene therapy technique, and compositions for use in treating disease conditions characterised by damaged or impaired nerves.
(FR)
L'invention concerne un procédé consistant à favoriser la ramification et/ou l'excroissance des axones et/ou des neurites et/ou à inhiber l'apoptose cellulaire chez un sujet. Le procédé comporte l'administration à un sujet ayant besoin d'un tel traitement d'une composition comprenant une enzyme sheddase ou analogue, ou un dérivé ou un activateur de celle-ci. L'invention concerne également un système de distribution utilisé en technique de thérapie génique, et des compositions utilisées dans le traitement d'états pathologiques caractérisés par l'endommagement ou la détérioration des nerfs.
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