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1. WO2007138155 - IMPROVED EXPRESSION OF TUBERCULOSIS VACCINE PROTEINS IN PLANTS

Publication Number WO/2007/138155
Publication Date 06.12.2007
International Application No. PCT/FI2007/000147
International Filing Date 30.05.2007
IPC
C12N 15/82 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells
A61K 39/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
04Mycobacterium, e.g. Mycobacterium tuberculosis
CPC
C12N 15/8258
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells ; , e.g. plant artificial chromosomes (PACs)
8241Phenotypically and genetically modified plants via recombinant DNA technology
8242with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
8257for the production of primary gene products, e.g. pharmaceutical products, interferon
8258for the production of oral vaccines (antigens) or immunoglobulins
Applicants
  • DOROKHOV, Yuri Leonidovich [RU]/[RU]
  • KORPELA, Timo [FI]/[FI]
  • ATABEKOV, Joseph Grigorievich [RU]/[RU]
Inventors
  • DOROKHOV, Yuri Leonidovich
  • KORPELA, Timo
  • ATABEKOV, Joseph Grigorievich
Common Representative
  • KORPELA, Timo
Priority Data
2006053301.06.2006FI
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED EXPRESSION OF TUBERCULOSIS VACCINE PROTEINS IN PLANTS
(FR) EXPRESSION AMÉLIORÉE DE PROTÉINES DU VACCIN CONTRE LA TUBERCULOSE DANS DES VÉGÉTAUX
Abstract
(EN)
The present invention provides constructs and methods for expression and accumulation of tuberculosis vaccine proteins in tissue or organ of a plant. The proteins are obtained by transient expression in and/or stable transformation of plants with non-replicating genes or virus-based vector cDNAs encoding the proteins. The genes include cellular compartment-specific, regulatory and/or affinity purification tag sequences. The plant tissue fractions containing the tuberculosis vaccine proteins themselves or after purification are useful as a tuberculosis vaccine.
(FR)
L'invention concerne des constructions et des procédés permettant l'expression et l'accumulation de protéines du vaccin contre la tuberculose dans un tissu ou un organe végétal. Lesdites protéines sont obtenues par l'expression transitoire dans des végétaux et/ou la transformation stable de végétaux avec des gènes non réplicatifs ou des ADNc à vecteur viral codant pour lesdites protéines. Les gènes contiennent des séquences régulatrices et/ou marqueurs de purification par affinité à compartiments cellulaires spécifiques. Les fractions de tissu végétal contenant les protéines du vaccin contre la tuberculose soit en elles-mêmes soit après purification sont utiles en tant que vaccin contre la tuberculose.
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