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1. WO2007138038 - NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE

Publication Number WO/2007/138038
Publication Date 06.12.2007
International Application No. PCT/EP2007/055169
International Filing Date 29.05.2007
IPC
C07D 471/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
08Bridged systems
A61K 31/551 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
06Antiabortive agents; Labour repressants
Applicants
  • NeuroSearch A/S [DK]/[DK] (AllExceptUS)
  • PETERS, Dan [SE]/[DK] (UsOnly)
  • OLSEN, Gunnar, M. [DK]/[DK] (UsOnly)
  • NIELSEN, Elsebet, Østergaard [DK]/[DK] (UsOnly)
  • TIMMERMANN, Daniel, B. [DK]/[DK] (UsOnly)
  • LOECHEL, Steven, Charles [DK]/[DK] (UsOnly)
Inventors
  • PETERS, Dan
  • OLSEN, Gunnar, M.
  • NIELSEN, Elsebet, Østergaard
  • TIMMERMANN, Daniel, B.
  • LOECHEL, Steven, Charles
Common Representative
  • NeuroSearch A/S
Priority Data
60/809,02430.05.2006US
PA 2006 0073130.05.2006DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
(FR) NOUVEAUX DÉRIVÉS DE 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYLE ET LEUR UTILISATION MÉDICALE
Abstract
(EN)
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar represents a phenyl group, which phenyl is substituted with methylenedioxy or ethylenedioxy.
(FR)
Nouveaux dérivés de 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyle et leur utilisation dans la fabrication de compositions pharmaceutiques. Il est apparu que les composés de l'invention étaient des ligands cholinergiques au niveau des récepteurs de l'acétylcholine nicotinique et des modulateurs des récepteurs et des transporteurs de la monoamine. Compte tenu de leur profil pharmacologique, ces composés peuvent convenir pour le traitement de maladies et de troubles aussi divers que celles et ceux en rapport avec le système cholinergique du système nerveux central, du système nerveux périphérique, de maladies ou de troubles associés à la contraction des muscles lisses, de maladies et de troubles d'origine endocrinienne, de maladies et de troubles associés à la neuro-dégénérescence, de maladies et de troubles en rapport avec l'inflammation, la douleur et les symptômes de sevrage dus à l'arrêt de l'abus de substances chimiques. Ar représente un groupe phényle, lequel phényle est substitué par un méthylènedioxy ou un éthylènedioxy.
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