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1. WO2007137513 - A TYPE OF NOVEL 2'-α-HYDROXYALKYL TAXEL COMPOUNDS AND THE PREPARATION METHODS THEREOF

Publication Number WO/2007/137513
Publication Date 06.12.2007
International Application No. PCT/CN2007/001733
International Filing Date 29.05.2007
IPC
C07D 305/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
14condensed with carbocyclic rings or ring systems
C07D 493/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
A61K 31/337 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
A61K 31/335 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 305/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atoms as the only ring hetero atoms
14condensed with carbocyclic rings or ring systems
Applicants
  • 中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN]/[CN]
  • 南发俊 NAN, Fajun [CN]/[CN] (UsOnly)
  • 李佳 LI, Jia [CN]/[CN] (UsOnly)
  • 周净 ZHOU, Jing [CN]/[CN] (UsOnly)
  • 谢传明 XIE, Chuanming [CN]/[CN] (UsOnly)
  • 张仰明 ZHANG, Yangming [CN]/[CN] (UsOnly)
Inventors
  • 南发俊 NAN, Fajun
  • 李佳 LI, Jia
  • 周净 ZHOU, Jing
  • 谢传明 XIE, Chuanming
  • 张仰明 ZHANG, Yangming
Agents
  • 北京金信联合知识产权代理有限公司 KINGSOUND & PARTNERS
Priority Data
200610027023.729.05.2006CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) A TYPE OF NOVEL 2'-α-HYDROXYALKYL TAXEL COMPOUNDS AND THE PREPARATION METHODS THEREOF
(FR) NOUVEAU TYPE DE COMPOSÉS 2'-α-HYDROXYALKYL TAXEL ET LEURS PROCÉDÉS DE PRÉPARATION
(ZH) 一类新颖的2' -α-羟烷基紫杉烷类化合物及其制备方法
Abstract
(EN)
The present application discloses a type of 2'-α-hydroxyalkyl taxel compounds with following formula (I), the compositions containing the same and uses thereof. These compounds can effectively inhibit the growth of tumor cells, especially can effectively inhibit the growth of tumor cells having multi-drugs resistance (such as MCF-7/ADR), which are better than Paclitaxel (Taxol®) or Docetaxel (Taxotere®).
(FR)
L'invention concerne un type de composés 2'-α-hydroxyalkyl taxel de formule suivante (I), des compositions les contenant et leurs utilisations. Ces composés peuvent efficacement inhiber la croissance de cellules tumorales, notamment celles résistantes aux médicaments multiples (telles que les cellules MCF-7/ADR). Ces composés sont plus efficaces que le Paclitaxel (Taxol®) ou le Docetaxel (Taxotere®).
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