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1. WO2007137414 - OVEREXPRESSION OF INTEGRIN LINKED KINASE (ILK) TO IMPROVE POST-INFARCT REMODELING

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[ EN ]

CLAIMS

What is claimed is:

Claim 1. A process for enhancing post-infarction cardiac remodeling comprising: genetic induction of over-expression of integrin linked kinase (ILK).

Claim 2. A process for quantifying ILK expression levels comprising determining guanisine triphosphate(GTP) loading as a measurement of levels of small G-protein Rac-1.

Claim 3. A process for inducing angiogenesis or angiostasis by moderation of expression of ILK by genetic manipulation.

Claim 4. A process for diagnosing human ventricular hypertrophy comprising:
determining a level of ILK protein expression and comparing it to a threshold level of

ILK protein expression;
wherein increased expression above threshold levels of ILK protein is diagnostic of human ventricular hypertrophy.