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1. WO2007137410 - BIOMARKERS FOR DIAGNOSING MULTIPLE SCLEROSIS, AND METHODS THEREOF

Publication Number WO/2007/137410
Publication Date 06.12.2007
International Application No. PCT/CA2007/000932
International Filing Date 24.05.2007
IPC
C07C 59/62 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
62containing rings other than six-membered aromatic rings
C07C 235/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04the carbon skeleton being acyclic and saturated
08having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
C07C 59/105 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
01Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
10Polyhydroxy carboxylic acids
105having five or more carbon atoms, e.g. aldonic acids
C07D 311/72 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
04Benzo pyrans, not hydrogenated in the carbocyclic ring
58other than with oxygen or sulfur atoms in position 2 or 4
70with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
723, 4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
C07F 9/09 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
C07F 9/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
10Phosphatides, e.g. lecithin
CPC
C07C 235/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04the carbon skeleton being acyclic and saturated
08having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
C07C 2601/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
16the ring being unsaturated
C07C 59/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
42containing hydroxy or O-metal groups
46containing rings other than six-membered aromatic rings
C07C 59/62
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
62containing rings other than six-membered aromatic rings
C07D 311/72
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
58other than with oxygen or sulfur atoms in positions 2 or 4
70with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
723,4-Dihydro-derivatives having in position 2 at least one methyl radical and in position 6 an oxygen atom, e.g. tocopherols
C07F 9/103
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P—C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
10Phosphatides, e.g. lecithin
103Extraction or purification by physical or chemical treatment of natural phosphatides; Preparation of compositions containing phosphatides of unknown structure
Applicants
  • PHENOMENOME DISCOVERIES INC. [CA]/[CA] (AllExceptUS)
  • COOK, Lisa [CA]/[CA] (UsOnly)
Inventors
  • COOK, Lisa
Agents
  • ERRATT, Judy A.
Priority Data
60/803,26726.05.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOMARKERS FOR DIAGNOSING MULTIPLE SCLEROSIS, AND METHODS THEREOF
(FR) BIOMARQUEURS ET MÉTHODES POUR DIAGNOSTIQUER LA SCLÉROSE EN PLAQUES
Abstract
(EN)
The present invention describes methods for the diagnosis and differential diagnosis of the different forms of multiple sclerosis The methods measure the intensities of specific small molecules called metabolites in samples from patients with clinically diagnosed relapsmg-remittmg or primary-progressive forms of multiple sclerosis and compare these intensities to the intensities observed in a population of healthy individuals, thus identifying markers of multiple sclerosis A method is also provided for the differential diagnosis of subjects afflicted with relapsing- renitting multiple sclerosis from secondary-progressive multiple sclerosis.
(FR)
La présente invention concerne des méthodes pour le diagnostic et le diagnostic différentiel de différentes formes de sclérose en plaques. Les méthodes mesurent les intensités de petites molécules spécifiques appelées métabolites dans des échantillons provenant de patients pour lesquels on a diagnostiqué une forme clinique récidivante-rechutante ou une forme primaire progressive de sclérose en plaques et comparent ces intensités aux intensités observées dans une population d'individus sains, identifiant ainsi des marqueurs de sclérose en plaques. L'invention concerne aussi une méthode pour le diagnostic différentiel de sujets atteints de la sclérose en plaques récidivante-rechutante provenant de la sclérose en plaques secondaire progressive.
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