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1. WO2007137366 - DIAGNOSTIC AND PROGNOSTIC INDICATORS OF CANCER

Publication Number WO/2007/137366
Publication Date 06.12.2007
International Application No. PCT/AU2007/000768
International Filing Date 31.05.2007
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6837
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
6837using probe arrays or probe chips
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/118
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
118Prognosis of disease development
C12Q 2600/136
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
136Screening for pharmacological compounds
G16B 25/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
25ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
G16B 40/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Applicants
  • TELETHON INSTITUTE FOR CHILD HEALTH RESEARCH [AU]/[AU] (AllExceptUS)
  • KEES, Ursula, Rosemary [AU]/[AU] (UsOnly)
  • FIRTH, Martin [AU]/[AU] (UsOnly)
  • DE KLERK, Nicholas [AU]/[AU] (UsOnly)
  • HOFFMANN, Katrin [DE]/[AU] (UsOnly)
Inventors
  • KEES, Ursula, Rosemary
  • FIRTH, Martin
  • DE KLERK, Nicholas
  • HOFFMANN, Katrin
Agents
  • GRIFFITH HACK
Priority Data
200690293931.05.2006AU
200690294031.05.2006AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIAGNOSTIC AND PROGNOSTIC INDICATORS OF CANCER
(FR) INDICATEURS DE DIAGNOSTIC ET DE PRONOSTIC DU CANCER
Abstract
(EN)
The present invention relates generally to the field of cancer research. The present invention also relates to a method of determining a predictive relationship between data related to gene expression levels and an outcome related to a disease or disorder, and a classifier for using the predictive relationship. More particularly, the present invention relates to A method of expression profiling for pre-B ALL, comprising the steps of: (a) providing biological samples from individuals with or without pre-B ALL; (b) isolating nucleic acid molecules from said biological samples; (c) measuring the expression levels of said nucleic acid molecules; (d) performing a first supervised analysis on data obtained from step (c), wherein said first supervised analysis will classify said individuals with or without pre-B ALL into distinct subgroups; and (e) performing a second supervised analysis on data obtained from step (d), wherein said second supervised analysis will classify said individuals further.
(FR)
La présente invention concerne d'une manière générale le domaine de la recherche sur le cancer. La présente invention concerne également un procédé permettant de déterminer une relation prédictive entre des données apparentées à des taux d'expression de gène et un résultat apparenté à une maladie ou à un trouble ainsi qu'un classificateur pour utiliser la relation prédictive. Plus particulièrement, la présente invention concerne un procédé de réalisation d'un profil d'expression pour pré-B ALL, comprenant les étapes consistant à (a) fournir des échantillons biologiques provenant d'individus avec ou sans pré-B ALL ; (b) isoler des molécules d'acide nucléique provenant desdits échantillons biologiques ; (c) mesurer les taux d'expression desdites molécules d'acide nucléique ; (d) réaliser une première analyse supervisée sur les données obtenues à l'étape (c), ladite première analyse supervisée classant lesdits individus avec ou sans pré-B ALL en différents sous-groupes ; (e) réaliser une seconde analyse supervisée sur les données obtenues à l'étape (d), ladite seconde analyse supervisée classant lesdits individus plus avant.
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