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1. WO2007136835 - METHODS AND CELLS FOR CREATING FUNCTIONAL DIVERSITY AND USES THEREOF

Publication Number WO/2007/136835
Publication Date 29.11.2007
International Application No. PCT/US2007/012077
International Filing Date 19.05.2007
IPC
C12N 15/09 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
CPC
C12N 15/1027
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
102Mutagenizing nucleic acids
1027by DNA shuffling, e.g. RSR, STEP, RPR
C12N 15/1031
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
102Mutagenizing nucleic acids
1031mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR
Applicants
  • CODON DEVICES, INC [US]/[US] (AllExceptUS)
  • CHURCH, George [US]/[US] (UsOnly)
  • BAYNES, Brian, M. [US]/[US] (UsOnly)
Inventors
  • CHURCH, George
  • BAYNES, Brian, M.
Agents
  • WALLER, Patrick, R.H.
Priority Data
60/801,83319.05.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND CELLS FOR CREATING FUNCTIONAL DIVERSITY AND USES THEREOF
(FR) PROCÉDÉS ET CELLULES POUR CRÉER UNE DIVERSITÉ FONCTIONNELLE ET UTILISATIONS DE CES PROCÉDÉS ET DE CES CELLULES
Abstract
(EN)
The invention provides methods and compositions relating to cells having altered functions, and the nucleic acids that impart those functions. Altered cellular function arises from in vivo directed recombination of genetic elements to yield a recombined nucleic acid. These methods and compositions may utilize altered host cells having altered recombination enzyme profiles and/or altered recombination sites. The invention involves in some aspects methods for assembling nucleic acid molecules, such as genomic DNA. Aspects of the invention also provide kits, compositions, devices, and systems for generating novel recombined nucleic acids and cells having altered cell function.
(FR)
L'invention concerne des procédés et des compositions se rapportant à des cellules présentant des fonctions modifiées, ainsi qu'aux acides nucléiques conférant ces fonctions. Une fonction cellulaire est modifiée par recombinaison in vivo d'éléments génétiques pour produire un acide nucléique recombiné. Ces procédés et ces compositions peuvent utiliser des cellules hôtes modifiées présentant des profils enzymatiques de recombinaison modifiés et/ou des sites de recombinaison modifiés. Certains aspects de l'invention concernent des procédés d'assemblage de molécules d'acides nucléiques, telles que l'ADN génomique. D'autres aspects de l'invention concernent des trousses, des compositions, des dispositifs et des systèmes pour générer de nouveaux acides nucléiques recombinés et des cellules présentant une fonction cellulaire modifiée.
Also published as
US12273098
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