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Machine translation
1. (WO2007136833) METHODS AND COMPOSITIONS FOR APTAMER PRODUCTION AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/136833    International Application No.:    PCT/US2007/012075
Publication Date: 29.11.2007 International Filing Date: 19.05.2007
IPC:
C12N 15/11 (2006.01), C12Q 1/68 (2006.01)
Applicants: CODON DEVICES, INC. [US/US]; Building 300, One Kendall Square, Cambridge, MA 02139 (US) (For All Designated States Except US).
CHURCH, George [US/US]; (US) (For US Only).
JACOBSON, Joseph, M. [US/US]; (US) (For US Only).
BAYNES, Brian, M. [US/US]; (US) (For US Only)
Inventors: CHURCH, George; (US).
JACOBSON, Joseph, M.; (US).
BAYNES, Brian, M.; (US)
Agent: WALLER, Patrick, R., H.; Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210 (US)
Priority Data:
60/801,834 19.05.2006 US
Title (EN) METHODS AND COMPOSITIONS FOR APTAMER PRODUCTION AND USES THEREOF
(FR) PROCÉDÉS ET COMPOSITIONS POUR LA PRODUCTION D'APTAMÈRES ET UTILISATIONS DE CES PROCÉDÉS ET DE CES COMPOSITIONS
Abstract: front page image
(EN)Certain aspects of the present invention provide methods for assembling nucleic acid libraries that represent large numbers of sequence variants. Some embodiments involve generating libraries of RNA molecules that can be subjected to in vivo screens or selections to identify one or more aptamers. Certain aspects of the invention provide cells that transcribe one or more different aptamers (e.g., 10) that each bind to a different ligand and are each fused to a different reporter RNA.
(FR)Certains aspects de la présente invention concernent des procédés d'assemblage de banques d'acides nucléiques représentant des nombres importants de variants de séquences. Certains modes de réalisation comprennent la génération de banques de molécules d'ARN pouvant être soumises à des criblages ou des sélections in vivo permettant d'identifier un ou plusieurs aptamères. Certains aspects de l'invention concernent des cellules qui transcrivent un ou plusieurs aptamères différents (p. ex. 10) qui se lient chacun à un ligand différent et sont chacun fusionnés à un ARN rapporteur différent.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)