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1. WO2007131991 - IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Publication Number WO/2007/131991
Publication Date 22.11.2007
International Application No. PCT/EP2007/054654
International Filing Date 14.05.2007
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
C07D 487/04 (2006.01)
A61K 31/4985 (2006.01)
A61P 19/02 (2006.01)
CPC
C07D 487/04
Applicants
  • GALAPAGOS N.V. [BE/BE]; Generaal De Wittelaan L11/A3 B-2800 Mechelen, BE (AllExceptUS)
  • BRYS, Reginald Christophe Xavier [BE/BE]; BE (UsOnly)
  • EDWARDS, Paul [GB/CA]; CA (UsOnly)
  • SCHMIDT, Wolfgang [DE/GB]; GB (UsOnly)
  • ANDREWS, Martin James Inglis [GB/BE]; BE (UsOnly)
  • CHAMBERS, Mark Stuart [GB/GB]; GB (UsOnly)
  • CLASE, Juha Andrew [GB/BE]; BE (UsOnly)
  • BIRAULT, Veronique [FR/GB]; GB (UsOnly)
  • HIRST, Kim Louise [GB/GB]; GB (UsOnly)
  • MACLEOD, Angus [GB/GB]; GB (UsOnly)
  • BAR, Gregory [FR/BE]; BE (UsOnly)
  • HARRIS, Clifford John [GB/GB]; GB (UsOnly)
  • HUXLEY, Philip [GB/GB]; GB (UsOnly)
Inventors
  • BRYS, Reginald Christophe Xavier; BE
  • EDWARDS, Paul; CA
  • SCHMIDT, Wolfgang; GB
  • ANDREWS, Martin James Inglis; BE
  • CHAMBERS, Mark Stuart; GB
  • CLASE, Juha Andrew; BE
  • BIRAULT, Veronique; GB
  • HIRST, Kim Louise; GB
  • MACLEOD, Angus; GB
  • BAR, Gregory; BE
  • HARRIS, Clifford John; GB
  • HUXLEY, Philip; GB
Agents
  • NICHOL, Maria; Galapagos NV Chesterford Research Park Little Chesterford Saffron Walden Essex CB10 1XL, GB
Priority Data
60/747,22315.05.2006US
60/928,53910.05.2007US
60/928,56810.05.2007US
60/928,60010.05.2007US
60/928,63910.05.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
(FR) COMPOSÉS D'IMIDAZOLOPYRAZINE UTILES POUR LE TRAITEMENT DES MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
Abstract
(EN)
Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.
(FR)
La présente invention concerne des composés innovants d'imidazo[1,2-a]pyrazine de formule (I) représentée ainsi : Les composés peuvent être préparés en tant que compositions pharmaceutiques et ils peuvent être utilisés pour la prévention et le traitement de diverses affections chez des mammifères dont les humains, y compris, à titre d'exemples non limitatifs, l'arthrite, l'inflammation et d'autres.
Also published as
Latest bibliographic data on file with the International Bureau