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1. WO2007128158 - TRANSITION METAL COMPLEXES FOR INHIBITING RESISTANCE IN THE TREATMENT OF CANCER AND METASTASIS

Publication Number WO/2007/128158
Publication Date 15.11.2007
International Application No. PCT/CH2007/000234
International Filing Date 09.05.2007
IPC
C07F 15/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
A61K 31/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
28Compounds containing heavy metals
CPC
A61K 31/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
28Compounds containing heavy metals
A61K 31/555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
555containing heavy metals, e.g. hemin, hematin, melarsoprol
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07F 15/002
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
0006compounds of the platinum group
002Osmium compounds
C07F 15/0033
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
0006compounds of the platinum group
0033Iridium compounds
Applicants
  • ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) [CH]/[CH] (AllExceptUS)
  • DYSON, Paul, Joseph [GB]/[CH] (UsOnly)
  • ANGE, Wee, Han [SG]/[CH] (UsOnly)
Inventors
  • DYSON, Paul, Joseph
  • ANGE, Wee, Han
Agents
  • GANGUILLET, Cyril
Priority Data
60/799,43309.05.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRANSITION METAL COMPLEXES FOR INHIBITING RESISTANCE IN THE TREATMENT OF CANCER AND METASTASIS
(FR) COMPLEXES DE MÉTAUX DE TRANSITION PERMETTANT d'INHIBER LA RÉSISTANCE DANS LE TRAITEMENT DU CANCER ET DES MÉTASTASES
Abstract
(EN)
The present invention relates to organometallic compounds useful in the treatment of metastasis. The organometallic compounds comprise a ligand that is convalently bound to a bioactive compound, which is an inhibitor of a resistance pathway or a derivative thereof. Preferably, the organometallic compounds are half-sandwich ('piano-stool') compounds. The compounds of the present invention offer a high variability with respect to the bioactive compound and to the nature of the ligand bound to a central transition metal.
(FR)
La présente invention concerne des composés organométalliques utiles dans le traitement des métastases. Les composés organométalliques comprennent un ligand lié de façon covalente à un composé bioactif, inhibiteur d'une voie de résistance ou dérivé. De préférence, les composés organométalliques sont des composés demi-sandwich ('tabouret de piano'). Les composés de la présente invention offrent une variabilité élevée en ce qui concerne le composé bioactif et la nature du ligand lié à un métal de transition central.
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