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1. (WO2007125414) 9A-SUBSTITUTED AZALIDES FOR THE TRATMENT OF MALARIA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/125414 International Application No.: PCT/IB2007/001216
Publication Date: 08.11.2007 International Filing Date: 01.05.2007
Chapter 2 Demand Filed: 29.02.2008
IPC:
A61K 31/395 (2006.01) ,A61K 31/7052 (2006.01) ,A61P 33/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06
Antimalarials
Applicants:
ALIHODZIC, Sulejman [HR/HR]; HR (UsOnly)
FAJDETIC, Andrea [HR/HR]; HR (UsOnly)
HUTINEC, Antun [HR/HR]; HR (UsOnly)
IVEZIC, Zrinka [HR/HR]; HR (UsOnly)
KUJUNDZIC, Nedjeljko [HR/HR]; HR (UsOnly)
RUPCIC, Renata [HR/HR]; HR (UsOnly)
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 10000 Zagreb, HR (AllExceptUS)
Inventors:
ALIHODZIC, Sulejman; HR
FAJDETIC, Andrea; HR
HUTINEC, Antun; HR
IVEZIC, Zrinka; HR
KUJUNDZIC, Nedjeljko; HR
RUPCIC, Renata; HR
Agent:
CRAWLEY, Karen; GlaxoSmithKline, CIP (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS, GB
Priority Data:
60/797,50503.05.2006US
Title (EN) 9A-SUBSTITUTED AZALIDES FOR THE TRATMENT OF MALARIA
(FR) 9A-AZALIDES SUBSTITUÉS
Abstract:
(EN) The present invention relates to novel 9a-substituted azalides having antimalarial activity. More particularly, the invention relates to 9a-substituted 9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A, 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-5-O-dedesosaminyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds having antimalarial activity, to the method of preparation, to the method of use, and to pharmaceutically acceptable derivatives thereof having antimalarial activity.
(FR) La présente invention concerne de nouveaux 9a-azalides substitués ayant une activité antipaludéenne. Plus précisément, l'invention concerne des composés de 9a-aza-9-deoxo-9-dihydro-9a-homoerythromycine A substituée en 9a, de 3-O-décladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycine A et de 3-O-décladinosyl-5-O-dédésosaminyl-9a-aza-9-deoxo-9-dihydro-9a-homoerytromycine A ayant une activité antipaludéenne, le procédé de préparation, le procédé d'utilisation et les dérivés pharmaceutiquement acceptables de ceux-ci ayant une activité antipaludéenne.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)