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1. WO2007123865 - TREATMENT OF INFLAMMATORY AND ULCERATIVE DISEASES OF THE BOWEL WITH OPIOID ANTAGONISTS

Publication Number WO/2007/123865
Publication Date 01.11.2007
International Application No. PCT/US2007/009228
International Filing Date 16.04.2007
IPC
A61K 31/4748 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4748forming part of bridged ring systems
CPC
A61K 31/4748
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4748forming part of bridged ring systems
A61K 31/485
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applicants
  • SMITH, Jill, P. [US]/[US]
Inventors
  • SMITH, Jill, P.
  • ZAGON, Ian, S.
  • ROGOSNITZKY, Moshe
Agents
  • SMITH, William, P.
Priority Data
60/745,11919.04.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENT OF INFLAMMATORY AND ULCERATIVE DISEASES OF THE BOWEL WITH OPIOID ANTAGONISTS
(FR) TRAITEMENT DE MALADIES INFLAMMATOIRES ET ULCÉREUSES DU CÔLON À L'AIDE D'ANTAGONISTES OPIOÏDES
Abstract
(EN)
Methods of pharmaceutical treatment comprising orally administering to a human subject having Crohn's disease or ulcerative colitis a therapeutic composition once per day in the evening or at bedtime, wherein the composition comprises about 3 mg to about 4.5 mg of naltrexone, nalmefene, naloxone, or a hydrochloride salt thereof, in an immediate release solid dosage formulation, are disclosed.
(FR)
L'invention concerne des méthodes pour le traitement de maladies inflammatoires et ulcéreuses du côlon (par exemple, maladie de Crohn et recto-colite hémorragique) à l'aide d'antagonistes opioïdes à faible dose (par exemple, naltrexone, nalméfène ou naloxone), des compositions pharmaceutiques à utiliser dans lesdites méthodes, et des méthodes pour la fabrication desdites compositions pharmaceutiques. Un mode de réalisation de l'invention concerne une méthode de traitement pharmaceutique qui consiste à administrer par voie orale à un humain atteint de la maladie de Crohn ou d'une recto-colite hémorragique une composition pharmaceutique thérapeutique une fois par jour le soir ou au coucher; ladite composition pharmaceutique comprenant entre environ 3 mg et environ 4,5 mg de naltrexone, nalméfène, naloxone, ou un sel d'hydrochlorure de ceux-ci dans une forme posologique solide à libération immédiate.
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