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1. WO2007122410 - PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS

Publication Number WO/2007/122410
Publication Date 01.11.2007
International Application No. PCT/GB2007/001504
International Filing Date 25.04.2007
IPC
C07D 495/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • F.HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
  • BAKER, Stewart, James [GB]/[GB] (UsOnly)
  • GOLDSMITH, Paul, John [GB]/[GB] (UsOnly)
  • HANCOX, Timothy, Colin [GB]/[GB] (UsOnly)
  • PEGG, Neil, Anthony [GB]/[GB] (UsOnly)
  • PRICE, Stephen [GB]/[GB] (UsOnly)
  • SHUTTLEWORTH, Stephen, Joseph [GB]/[GB] (UsOnly)
  • SOHAL, Sukhjit [GB]/[GB] (UsOnly)
Inventors
  • BAKER, Stewart, James
  • GOLDSMITH, Paul, John
  • HANCOX, Timothy, Colin
  • PEGG, Neil, Anthony
  • PRICE, Stephen
  • SHUTTLEWORTH, Stephen, Joseph
  • SOHAL, Sukhjit
Agents
  • KEEN, Celia, Mary
Priority Data
0608264.826.04.2006GB
0608397.627.04.2006GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS
(FR) DÉRIVÉS PYRIMIDINIQUES UTILISÉS COMME INHIBITEURS DE LA PI3K
Abstract
(EN) Thienopyrimidines of formula (Ia) or (Ib): wherein R1, R2, R3, are as defined in the claims.
(FR) L'invention concerne des thiénopyrimidines de formule (Ia) ou (Ib) : dans lesquelles R1, R2, R3 sont tels que définis dans les revendications.
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