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1. (WO2007121920) PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/121920 International Application No.: PCT/EP2007/003435
Publication Date: 01.11.2007 International Filing Date: 19.04.2007
IPC:
C07D 473/16 (2006.01) ,C07D 473/18 (2006.01) ,C07D 473/34 (2006.01) ,C07H 19/167 (2006.01) ,A61P 29/00 (2006.01) ,A61K 31/52 (2006.01) ,A61K 31/7076 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
02
with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
16
two nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
02
with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
18
one oxygen and one nitrogen atom, e.g. guanine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32
Nitrogen atom
34
attached in position 6, e.g. adenine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
167
with ribosyl as the saccharide radical
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7076
containing purines, e.g. adenosine, adenylic acid
Applicants:
NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4002 Basel, CH (AllExceptUS)
FAIRHURST, Robin, Alec [GB/GB]; GB (UsOnly)
TAYLOR, Roger, John [GB/GB]; GB (UsOnly)
COX, Brian [GB/GB]; GB (UsOnly)
Inventors:
FAIRHURST, Robin, Alec; GB
TAYLOR, Roger, John; GB
COX, Brian; GB
Agent:
LEON, Susanna; Novartis AG Corporate Intellectual Property CH-4002 Basel, CH
Priority Data:
0607947.921.04.2006GB
07101483.131.01.2007EP
Title (EN) PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS
(FR) COMPOSÉS ORGANIQUES
Abstract:
(EN) Purine derivatives of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. The compounds are useful for the treatment of a condition mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions comprising a purine derivative as active ingredient and a process for the preparation of these compounds.
(FR) La présente invention concerne un composé représenté par la formule (I), ou certains de ses stétéoisomères ou sels pharmaceutiquement admis. L'invention concerne également leur élaboration et leur utilisation comme produits pharmaceutiques. Dans la formule (I), les R1, R2 et R3 sont tels que définis dans les spécifications.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
DZDZP2008000672NO20084803MXMX/a/2008/013431KR1020080110925IL194396SG146723
VN20761EP2013211EP2322525ZA2008/08055JP2009534338US20100286126
ES2384337RU0002457209CN101472925CA2649215TN2008000407NZ571429
AU2007241343DK2013211IDW00200803408MYPI 20084072IN8034/DELNP/2008