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1. WO2007118903 - TRISUBSTITUTED 1,2,4-TRIAZOLES

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Publication Number WO/2007/118903
Publication Date 25.10.2007
International Application No. PCT/EP2007/053829
International Filing Date 19.04.2007
IPC
C07D 401/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 249/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
C07D 405/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61K 31/4196 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61K 31/4196
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants
  • JANSSEN PHARMACEUTICA N.V. [BE]/[BE] (AllExceptUS)
  • THURING, Johannes Wilhelmus John F. [NL]/[BE] (UsOnly)
  • MACDONALD, Gregor, James [GB]/[BE] (UsOnly)
  • LESAGE, Anne Simone Josephine [BE]/[BE] (UsOnly)
  • ZHUANG, Wei [CN]/[BE] (UsOnly)
  • DE BRUYN, Marcel Frans Leopold [BE]/[BE] (UsOnly)
  • VAN DEN KEYBUS, Frans Alfons Maria [BE]/[BE] (UsOnly)
  • VAN ROOSBROECK, Yves Emiel Maria [BE]/[BE] (UsOnly)
  • DINKLO, Theodorus [NL]/[BE] (UsOnly)
  • DUFFY, James Edward Stewart [GB]/[GB] (UsOnly)
Inventors
  • THURING, Johannes Wilhelmus John F.
  • MACDONALD, Gregor, James
  • LESAGE, Anne Simone Josephine
  • ZHUANG, Wei
  • DE BRUYN, Marcel Frans Leopold
  • VAN DEN KEYBUS, Frans Alfons Maria
  • VAN ROOSBROECK, Yves Emiel Maria
  • DINKLO, Theodorus
  • DUFFY, James Edward Stewart
Common Representative
  • JANSSEN PHARMACEUTICA N.V.
Priority Data
06112754.419.04.2006EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRISUBSTITUTED 1,2,4-TRIAZOLES
(FR) 1,2,4-TRIAZOLES TRISUBSTITUÉS
front page image
Abstract
(EN) The present invention relates to 3-aniIine-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
(FR) La présente invention concerne des dérivés 3-aniline-5-aryle de triazole de Formule (I) et des analogues ou des sels de qualité pharmaceutique desdits dérivés, ainsi que des procédés de synthèse desdits dérivés, des compositions pharmaceutiques les incluant et leur emploi en thérapie. L'invention concerne en particulier des modulateurs allostériques positifs des récepteurs nicotiniques de l'acétylcholine, un tel modulateur allostérique positif ayant la capacité d'augmenter l'efficacité des agonistes des récepteurs nicotiniques.
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