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1. (WO2007118903) TRISUBSTITUTED 1,2,4-TRIAZOLES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/118903 International Application No.: PCT/EP2007/053829
Publication Date: 25.10.2007 International Filing Date: 19.04.2007
IPC:
C07D 401/04 (2006.01) ,C07D 249/08 (2006.01) ,C07D 405/04 (2006.01) ,A61K 31/4196 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
249
Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
08
1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
THURING, Johannes Wilhelmus John F. [NL/BE]; BE (UsOnly)
MACDONALD, Gregor, James [GB/BE]; BE (UsOnly)
LESAGE, Anne Simone Josephine [BE/BE]; BE (UsOnly)
ZHUANG, Wei [CN/BE]; BE (UsOnly)
DE BRUYN, Marcel Frans Leopold [BE/BE]; BE (UsOnly)
VAN DEN KEYBUS, Frans Alfons Maria [BE/BE]; BE (UsOnly)
VAN ROOSBROECK, Yves Emiel Maria [BE/BE]; BE (UsOnly)
DINKLO, Theodorus [NL/BE]; BE (UsOnly)
DUFFY, James Edward Stewart [GB/GB]; GB (UsOnly)
JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30 B-2340 Beerse, BE (AllExceptUS)
Inventors:
THURING, Johannes Wilhelmus John F.; BE
MACDONALD, Gregor, James; BE
LESAGE, Anne Simone Josephine; BE
ZHUANG, Wei; BE
DE BRUYN, Marcel Frans Leopold; BE
VAN DEN KEYBUS, Frans Alfons Maria; BE
VAN ROOSBROECK, Yves Emiel Maria; BE
DINKLO, Theodorus; BE
DUFFY, James Edward Stewart; GB
Common
Representative:
JANSSEN PHARMACEUTICA N.V.; Turnhoutseweg 30 B-2340 Beerse, BE
Priority Data:
06112754.419.04.2006EP
Title (EN) TRISUBSTITUTED 1,2,4-TRIAZOLES
(FR) 1,2,4-TRIAZOLES TRISUBSTITUÉS
Abstract:
(EN) The present invention relates to 3-aniIine-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
(FR) La présente invention concerne des dérivés 3-aniline-5-aryle de triazole de Formule (I) et des analogues ou des sels de qualité pharmaceutique desdits dérivés, ainsi que des procédés de synthèse desdits dérivés, des compositions pharmaceutiques les incluant et leur emploi en thérapie. L'invention concerne en particulier des modulateurs allostériques positifs des récepteurs nicotiniques de l'acétylcholine, un tel modulateur allostérique positif ayant la capacité d'augmenter l'efficacité des agonistes des récepteurs nicotiniques.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)