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1. (WO2007115410) COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2007/115410 International Application No.: PCT/CA2007/000596
Publication Date: 18.10.2007 International Filing Date: 10.04.2007
IPC:
C07D 217/04 (2006.01) ,A61K 31/472 (2006.01) ,A61K 31/4725 (2006.01) ,A61K 31/497 (2006.01) ,A61K 31/501 (2006.01) ,C07D 401/04 (2006.01) ,C07D 401/14 (2006.01) ,C07D 413/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
217
Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02
with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
04
with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
472
Non-condensed isoquinolines, e.g. papaverine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
472
Non-condensed isoquinolines, e.g. papaverine
4725
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
Applicants:
VOHRA, Rahul [CA/CA]; CA (UsOnly)
GAN, Zhonghong [CA/CA]; CA (UsOnly)
WEI, Chang-Qing [CN/CA]; CA (UsOnly)
PRICE, Stephen [GB/GB]; GB (UsOnly)
DYKE, Hazel, Joan [GB/GB]; GB (UsOnly)
DECHAUX, Elsa, Amandine [FR/GB]; GB (UsOnly)
PAINCEPTOR PHARMA CORPORATION [CA/CA]; 7150 Albert-Einstein, Suite 100 St. Laurent, Québec H4S 2C1, CA (AllExceptUS)
Inventors:
VOHRA, Rahul; CA
GAN, Zhonghong; CA
WEI, Chang-Qing; CA
PRICE, Stephen; GB
DYKE, Hazel, Joan; GB
DECHAUX, Elsa, Amandine; GB
Agent:
CONN, David, L. ; Borden Ladner Gervais LLP World Exchange Plaza 100 Queen Street Suite 1100 Ottawa, Ontario K1P 1J9, CA
Priority Data:
60/791,08510.04.2006US
60/791,12610.04.2006US
60/791,17510.04.2006US
Title (EN) COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS
(FR) COMPOSITIONS ET MÉTHODES POUR CANAUX IONIQUES COMMANDÉS PAR PORTE
Abstract:
(EN) The present invention relates to compounds of the Formula (I),(II), (III), (IV) or (V) useful to modulate the activity of gated ion channels. The invention further relates to methods wherein said compounds are used to modulate gated ion channels comprised of at least one subunit which is a member of the DEG/ENaC, P2X or TRPV gene superfamilies. The activity of the gated ion channels which are modulated by compounds I-V are associated with pain, inflammatory disorders or neurological disorders.
(FR) L'invention concerne des composés de formule (I), (II), (III), (IV) ou (V) convenant pour la modulation de canaux ioniques commandés par porte. Elle concerne également des méthodes dans lesquelles lesdits composés s'utilisent pour moduler des canaux ioniques commandés par porte comprenant au moins une sous-unité faisant partie des superfamilles de gènes DEG/ENaC, P2X ou TRPV. L'activité des canaux ioniques commandés par porte qui sont modulés par des composés de formule I-V est associée à la douleur, à des troubles inflammatoires ou à des troubles neurologiques.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)