Processing

Please wait...

Settings

Settings

Goto Application

1. WO2007115409 - COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

Publication Number WO/2007/115409
Publication Date 18.10.2007
International Application No. PCT/CA2007/000595
International Filing Date 10.04.2007
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
C07D 209/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
40Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • PAINCEPTOR PHARMA CORPORATION [CA]/[CA] (AllExceptUS)
  • VOHRA, Rahul [CA]/[CA] (UsOnly)
  • GAN, Zhonghong [CA]/[CA] (UsOnly)
  • PRICE, Stephen [GB]/[GB] (UsOnly)
  • DYKE, Hazel, Joan [GB]/[GB] (UsOnly)
Inventors
  • VOHRA, Rahul
  • GAN, Zhonghong
  • PRICE, Stephen
  • DYKE, Hazel, Joan
Agents
  • CONN, David L.
Priority Data
60/791,08510.04.2006US
60/791,12610.04.2006US
60/791,17510.04.2006US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS
(FR) COMPOSITIONS ET PROCÉDÉS DESTINÉS À MODULER DES CANAUX IONIQUES COMMANDÉS
Abstract
(EN) Indole derivatives according to formula (I), (II) or (III) wherein R1 is a hydrogen atom, an alkyl or alkoxy group and X-Y together with their adjacent carbon atoms form a six membered ring involving a nitrogen heteroatom or not. These compounds and their pharmaceutically acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.
(FR) L'invention concerne des dérivés d'indole selon la formule (I), (II) ou (III), dans lequelles R1 représente un atome d'hydrogène, un groupe alkyle ou alcoxy et X-Y avec leurs atomes de carbone adjacents forment un cycle à six chaînons impliquant un hétéroatome d'azote ou non. Ces composés et leurs sels pharmaceutiquement acceptables sont utilisés afin de moduler des canaux inoniques commandés en vue de traiter la douleur, les troubles inflammatoires, les troubles neurologiques, ou les maladies associées aux systèmes gastro-intestinal ou génito-urinaire.
Latest bibliographic data on file with the International Bureau