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1. (WO2007115409) COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/115409 International Application No.: PCT/CA2007/000595
Publication Date: 18.10.2007 International Filing Date: 10.04.2007
IPC:
C07D 471/04 (2006.01) ,A61K 31/437 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Applicants:
VOHRA, Rahul [CA/CA]; CA (UsOnly)
GAN, Zhonghong [CA/CA]; CA (UsOnly)
PRICE, Stephen [GB/GB]; GB (UsOnly)
DYKE, Hazel, Joan [GB/GB]; GB (UsOnly)
PAINCEPTOR PHARMA CORPORATION [CA/CA]; 7150 Albert-Einstein, Suite 100 St. Laurent, Québec H4S 2C1, CA (AllExceptUS)
Inventors:
VOHRA, Rahul; CA
GAN, Zhonghong; CA
PRICE, Stephen; GB
DYKE, Hazel, Joan; GB
Agent:
CONN, David L. ; Borden Ladner Gervais Llp World Exchange Plaza 100 Queen Street, Suite 1100 Ottawa, Ontario K1P 1J9, CA
Priority Data:
60/791,08510.04.2006US
60/791,12610.04.2006US
60/791,17510.04.2006US
Title (EN) COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS
(FR) COMPOSITIONS ET PROCÉDÉS DESTINÉS À MODULER DES CANAUX IONIQUES COMMANDÉS
Abstract:
(EN) Indole derivatives according to formula (I), (II) or (III) wherein R1 is a hydrogen atom, an alkyl or alkoxy group and X-Y together with their adjacent carbon atoms form a six membered ring involving a nitrogen heteroatom or not. These compounds and their pharmaceutically acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.
(FR) L'invention concerne des dérivés d'indole selon la formule (I), (II) ou (III), dans lequelles R1 représente un atome d'hydrogène, un groupe alkyle ou alcoxy et X-Y avec leurs atomes de carbone adjacents forment un cycle à six chaînons impliquant un hétéroatome d'azote ou non. Ces composés et leurs sels pharmaceutiquement acceptables sont utilisés afin de moduler des canaux inoniques commandés en vue de traiter la douleur, les troubles inflammatoires, les troubles neurologiques, ou les maladies associées aux systèmes gastro-intestinal ou génito-urinaire.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)