Processing

Please wait...

Settings

Settings

Goto Application

1. WO2007115408 - COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

Publication Number WO/2007/115408
Publication Date 18.10.2007
International Application No. PCT/CA2007/000594
International Filing Date 10.04.2007
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/472 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
A61K 31/4745 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4738ortho- or peri-condensed with heterocyclic ring systems
4745condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
C07D 209/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
40Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • PAINCEPTOR PHARMA CORPORATION [CA]/[CA] (AllExceptUS)
  • VOHRA, Rahul [CA]/[CA] (UsOnly)
  • WEI, Chang-Qing [CN]/[CA] (UsOnly)
  • GAN, Zhonghong [CA]/[CA] (UsOnly)
  • DEMNITZ, Joachim [DE]/[DK] (UsOnly)
  • AHRING, Philip, K. [DK]/[DK] (UsOnly)
Inventors
  • VOHRA, Rahul
  • WEI, Chang-Qing
  • GAN, Zhonghong
  • DEMNITZ, Joachim
  • AHRING, Philip, K.
Agents
  • CONN, David L.
Priority Data
60/791,08510.04.2006US
60/791,12610.04.2006US
60/791,17510.04.2006US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS
(FR) COMPOSITIONS ET PROCÉDÉS DESTINÉS À MODULER DES CANAUX IONIQUES COMMANDÉS
Abstract
(EN) The alleged invention relates to indole derivatives according to formula 1, namely, wherein X is CH2, O, NR2 or NOR2 and wherein A is preferably a six membered ring involving a nitrogen heteroatom. These compounds and their pharmaceutical acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.
(FR) Cette invention concerne des dérivés d'indole selon la formule1, dans laquelle X représente, notamment, CH2, O, NR2 ou NOR2 et A représente, de préférence, un cycle à six chaînons impliquant un hétéroatome d'azote. Ces composés et leurs sels pharmaceutiquement acceptables sont utilisés afin de moduler des canaux ioniques commandé en vue de traiter la douleur, les troubles inflammatoires, les troubles neurologiques, ou les maladies associées aux systèmes gastro-intestinal ou génito-urinaire.
Latest bibliographic data on file with the International Bureau