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1. WO2007102061 - PRODRUGS OF BENZOQUINOLIZINE-2-CARBOXYLIC ACID

Publication Number WO/2007/102061
Publication Date 13.09.2007
International Application No. PCT/IB2007/000484
International Filing Date 01.03.2007
IPC
A61K 31/4375 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
C07D 455/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
455Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo quinolizines, e.g. berberine
03containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo quinolizines, e.g. berberine
04containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
06containing benzo quinolizine ring systems
CPC
A61K 31/4375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • WOCKHARDT LTD [IN]/[IN] (AllExceptUS)
  • PATEL, Mahesh, Vithalbhai [IN]/[IN]
  • DESAI, Vijaya, Narayan [IN]/[IN]
  • DESHPANDE, Prasad, Keshav [IN]/[IN]
  • YEOLE, Ravindra, Dattatrya [IN]/[IN]
  • KALE, Rajesh, Prabhakar [IN]/[IN]
Inventors
  • PATEL, Mahesh, Vithalbhai
  • DESAI, Vijaya, Narayan
  • DESHPANDE, Prasad, Keshav
  • YEOLE, Ravindra, Dattatrya
  • KALE, Rajesh, Prabhakar
Agents
  • ESWARAN, Iyer, K.
Priority Data
321/MUM/200607.03.2006IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PRODRUGS OF BENZOQUINOLIZINE-2-CARBOXYLIC ACID
(FR) PROMÉDICAMENTS D'ACIDE BENZOQUINOLIZINE-2-CARBOXYLIQUE
Abstract
(EN) The instant invention relates to novel prodrugs of optically pure benzoquinolizine-2- carboxylic acid and pharmaceutical compositions that include the prodrugs. In particular, the present invention relates to the sulfonic acid salts of L-alanine and L- valine prodrugs of S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-l-yl)-5-methyl-l-oxo-lH,5H-benzo[i,j] quinolizine-2-carboxylic acid. The compounds and compositions of the invention can be used to treat bacterial Gram-positive, Gram-negative and anaerobic infections, especially infections caused by resistant Gram-positive organism and Gram-negative organism, mycobacterial infections and emerging nosocomial pathogen infections.
(FR) La présente invention concerne de nouveaux promédicaments d'acide benzoquinolizine-2- carboxylique pur et des compositions pharmaceutiques comprenant les promédicaments. En particulier, la présente invention concerne des sels d'acide sulfonique de L-alanine et L- valine promédicaments de l'acide S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-l-yl)-5-methyl-l-oxo-lH,5H-benzo[i,j] quinolizine-2-carboxylique. Les composés et compositions selon l'invention peuvent être utilisés pour traiter des infections bactériennes Gram-positif, Gram-négatif et anaérobies, des infections mycobactériennes et des infections pathogènes nosocomiales émergentes.
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