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Machine translation
1. (WO2007098500) A METHOD FOR IMPROVING THE PHARMACEUTIC PROPERTIES OF MICROPARTICLES COMPRISING DIKETOPIPERAZINE AND AN ACTIVE AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/098500    International Application No.:    PCT/US2007/062626
Publication Date: 30.08.2007 International Filing Date: 22.02.2007
Chapter 2 Demand Filed:    05.03.2008    
IPC:
A61K 38/28 (2006.01), A61K 9/16 (2006.01), A61P 3/10 (2006.01)
Applicants: MANNKIND CORPORATION [US/US]; 28903 North Avenue Paine, Valencia, CA 91355 (US) (For All Designated States Except US).
WILSON, Bryan R. [US/US]; (US) (For US Only).
GRANT, Marshall [US/US]; (US) (For US Only)
Inventors: WILSON, Bryan R.; (US).
GRANT, Marshall; (US)
Agent: CULLMAN, Louis C.; Kirkpatrick & Lockhart Preston Gates Ellis LLP, 1900 Main Street, Suite 600, Irvine, CA 92614-7319 (US).
BASSETT, Richard; Potter Clarkson LLP, Park View House, 58 The Ropewalk, Nottingham NG1 5DD (GB)
Priority Data:
60/776,605 22.02.2006 US
Title (EN) A METHOD FOR IMPROVING THE PHARMACEUTIC PROPERTIES OF MICROPARTICLES COMPRISING DIKETOPIPERAZINE AND AN ACTIVE AGENT
(FR) PROCÉDÉ POUR AMÉLIORER LES PROPRIÉTÉS PHARMACEUTIQUES DE MICROPARTICULES COMPRENANT DE LA DICÉTOPIPÉRAZINE ET UN AGENT ACTIF
Abstract: front page image
(EN)Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
(FR)L'invention concerne des procédés de séchage d'une particule. Plus spécifiquement, l'invention concerne une formulation particulaire à base de dicétopipérazine et d'insuline desséchée par atomisation, présentant des performances aérodynamiques améliorées, et dans laquelle l'agent actif est plus stable et plus efficacement administré comparé à celui de la formulation à base de dicétopipérazine et d'insuline lyophilisée. Les poudres sèches sont utiles en tant que formulations pharmaceutiques pour l'administration pulmonaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)