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1. (WO2007097931) AMINOTETRAHYDROPYRANS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/097931    International Application No.:    PCT/US2007/003558
Publication Date: 30.08.2007 International Filing Date: 09.02.2007
IPC:
A61K 31/519 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
BIFTU, Tesfaye [US/US]; (US) (For US Only).
CALDWELL, Charles, G. [US/US]; (US) (For US Only).
WEBER, Ann, E. [US/US]; (US) (For US Only).
CHEN, Ping [US/US]; (US) (For US Only).
QIAN, Xiaoxia [CN/US]; (US) (For US Only).
FENG, Danqing [US/US]; (US) (For US Only).
COX, Jason, M. [US/US]; (US) (For US Only)
Inventors: BIFTU, Tesfaye; (US).
CALDWELL, Charles, G.; (US).
WEBER, Ann, E.; (US).
CHEN, Ping; (US).
QIAN, Xiaoxia; (US).
FENG, Danqing; (US).
COX, Jason, M.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US)
Priority Data:
60/773,809 15.02.2006 US
Title (EN) AMINOTETRAHYDROPYRANS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
(FR) AMINOTÉTRAHYDROPYRANNES EN TANT QU'INHIBITEURS DE DIPEPTIDYLPEPTIDASE-IV DANS LE TRAITEMENT PROPHYLACTIQUE OU THÉRAPEUTIQUE DU DIABÈTE
Abstract: front page image
(EN)The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
(FR)La présente invention concerne de nouveaux aminotétrahydropyrannes substitués de formule structurale I qui sont des inhibiteurs de l'enzyme dipeptidylpeptidase-IV et qui peuvent être employés dans le traitement prophylactique ou thérapeutique de maladies dans lesquels l'enzyme dipeptidylpeptidase-IV est impliquée, comme le diabète, et particulièrement le diabète de type 2. La présente invention concerne également des compositions pharmaceutiques comprenant lesdits composés, ainsi que l'emploi desdits composés et compositions dans le traitement prephylactique ou thérapeutique de maladies dans lesquelles l'enzyme dipeptidylpeptidase-IV est impliquée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)