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Machine translation
1. (WO2007097720) METHOD AND REAGENTS FOR TREATING HEPATIC FIBROSIS AND INFLAMMATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/097720    International Application No.:    PCT/SG2007/000111
Publication Date: 30.08.2007 International Filing Date: 23.04.2007
IPC:
C12Q 1/37 (2006.01), A61K 31/00 (2006.01)
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 20 Biopolis Way, #07-01, Centros, Singapore 138668 (SG) (For All Designated States Except US).
MAUBACH, Gunter [DE/SG]; (SG) (For US Only).
ZHOU, Lang [US/SG]; (SG) (For US Only).
LIM, Michelle, Chin Chia [SG/SG]; (SG) (For US Only)
Inventors: MAUBACH, Gunter; (SG).
ZHOU, Lang; (SG).
LIM, Michelle, Chin Chia; (SG)
Agent: ELLA CHEONG SPRUSON & FERGUSON (SINGAPORE) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG)
Priority Data:
60/774,543 21.02.2006 US
Title (EN) METHOD AND REAGENTS FOR TREATING HEPATIC FIBROSIS AND INFLAMMATION
(FR) MÉTHODE ET RÉACTIFS POUR TRAITER FIBROSE ET INFLAMMATION HÉPATIQUES
Abstract: front page image
(EN)The invention relates to methods for identifying an anti-fibrotic or anti-inflammatory agent comprising determining cathepsin S expression in activated hepatic stellate cells which have been exposed to a test compound and comparing expression to non-exposed hepatic stellate cells. The invention also relates to methods for treating a disorder characterised or caused by hepatic fibrosis or inflammation, comprising administering a cathepsin S inhibitor to a subject.
(FR)L'invention concerne des méthodes et des réactifs pour traiter une fibrose et une inflammation hépatiques, des méthodes pour identifier des composés ayant des propriétés anti-fibrotiques et anti-inflammatoires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)