WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007097455) NOVEL COMPOUND ISOLATED FROM PLANT 'PAU-FERRO'
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/097455    International Application No.:    PCT/JP2007/053614
Publication Date: 30.08.2007 International Filing Date: 27.02.2007
IPC:
C07D 307/80 (2006.01), A61K 31/343 (2006.01), A61K 31/353 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), A61P 43/00 (2006.01), C07D 493/04 (2006.01)
Applicants: MEIJI DAIRIES CORPORATION [JP/JP]; 2-10, Shinsuna 1-chome, Koto-ku, Tokyo 1368908 (JP) (For All Designated States Except US).
NOZAKI, Hiroshi [JP/JP]; (JP) (For US Only).
YAMADA, Masashi [JP/JP]; (JP) (For US Only).
SUZUKI, Hiroto [JP/JP]; (JP) (For US Only).
SUMA, Yukie [JP/JP]; (JP) (For US Only).
ISHII, Manabu [JP/JP]; (JP) (For US Only)
Inventors: NOZAKI, Hiroshi; (JP).
YAMADA, Masashi; (JP).
SUZUKI, Hiroto; (JP).
SUMA, Yukie; (JP).
ISHII, Manabu; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
2006-051117 27.02.2006 JP
Title (EN) NOVEL COMPOUND ISOLATED FROM PLANT 'PAU-FERRO'
(FR) COMPOSE INNOVANT ISOLE DE LA PLANTE 'PAU-FERRO'
(JA) パウ・フェロから単離された新規化合物
Abstract: front page image
(EN)Active ingredients contained in the stem of 'Pau-Ferro', a plant belonging to the family Leguminosae, the genus Caesalpiniaceae inhabiting in Middle and South America are isolated, and are examined with respect to the inhibitory effect on type II DNA topoisomerase. As a result, it is found that an extract from the plant 'Pau-Ferro' is excellent in type II DNA topoisomerase inhibiting activity, cell growth inhibiting activity and apoptosis inducing activity and therefore is useful as a therapeutic or prophylactic agent for various cancerous diseases.
(FR)La présente invention concerne des matières actives qui se trouvent dans la tige du 'Pau-Ferro', plante du genre Caesalpinia de la famille des légumineuses, qui vit en Amérique centrale et en Amérique du Sud. Ces matières actives ont été isolées et leur effet inhibiteur sur l'ADN topoisomérase de type II a été examiné, ce qui a permis de constater qu'un extrait de la plante 'Pau-Ferro' présente d'excellentes activités d'inhibition de l'ADN topoisomérase de type II, d'inhibition de la croissance cellulaire et d'induction de l'apoptose et qu'il est donc utilisable en tant qu'agent thérapeutique ou prophylactique contre divers cancers.
(JA) 本発明者らは、中南米に生息するマメ科ジャケツイバラ属植物パウ・フェロの幹部に含まれる活性成分の分離を行い、これらの成分について、II型DNAトポイソメラーゼに対する阻害活性の検討を行った。その結果、パウ・フェロの抽出物は優れたII型DNAトポイソメラーゼ阻害作用、細胞増殖抑制作用、およびアポトーシス誘導作用を持ち、各種癌疾患の治療または予防剤として有用であることを見出した。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)