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1. WO2007097455 - NOVEL COMPOUND ISOLATED FROM PLANT 'PAU-FERRO'

Publication Number WO/2007/097455
Publication Date 30.08.2007
International Application No. PCT/JP2007/053614
International Filing Date 27.02.2007
IPC
C07D 307/80 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
78Benzo furans; Hydrogenated benzo furans
79with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
80Radicals substituted by oxygen atoms
A61K 31/343 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/353 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 307/80
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
78Benzo [b] furans; Hydrogenated benzo [b] furans
79with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals directly attached to carbon atoms of the hetero ring
80Radicals substituted by oxygen atoms
C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 明治乳業株式会社 MEIJI DAIRIES CORPORATION [JP]/[JP] (AllExceptUS)
  • 野崎 浩 NOZAKI, Hiroshi [JP]/[JP] (UsOnly)
  • 山田 昌司 YAMADA, Masashi [JP]/[JP] (UsOnly)
  • 鈴木 啓仁 SUZUKI, Hiroto [JP]/[JP] (UsOnly)
  • 須磨 幸恵 SUMA, Yukie [JP]/[JP] (UsOnly)
  • 石井 学 ISHII, Manabu [JP]/[JP] (UsOnly)
Inventors
  • 野崎 浩 NOZAKI, Hiroshi
  • 山田 昌司 YAMADA, Masashi
  • 鈴木 啓仁 SUZUKI, Hiroto
  • 須磨 幸恵 SUMA, Yukie
  • 石井 学 ISHII, Manabu
Agents
  • 清水 初志 SHIMIZU, Hatsushi
Priority Data
2006-05111727.02.2006JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL COMPOUND ISOLATED FROM PLANT 'PAU-FERRO'
(FR) COMPOSE INNOVANT ISOLE DE LA PLANTE 'PAU-FERRO'
(JA) パウ・フェロから単離された新規化合物
Abstract
(EN)
Active ingredients contained in the stem of 'Pau-Ferro', a plant belonging to the family Leguminosae, the genus Caesalpiniaceae inhabiting in Middle and South America are isolated, and are examined with respect to the inhibitory effect on type II DNA topoisomerase. As a result, it is found that an extract from the plant 'Pau-Ferro' is excellent in type II DNA topoisomerase inhibiting activity, cell growth inhibiting activity and apoptosis inducing activity and therefore is useful as a therapeutic or prophylactic agent for various cancerous diseases.
(FR)
La présente invention concerne des matières actives qui se trouvent dans la tige du 'Pau-Ferro', plante du genre Caesalpinia de la famille des légumineuses, qui vit en Amérique centrale et en Amérique du Sud. Ces matières actives ont été isolées et leur effet inhibiteur sur l'ADN topoisomérase de type II a été examiné, ce qui a permis de constater qu'un extrait de la plante 'Pau-Ferro' présente d'excellentes activités d'inhibition de l'ADN topoisomérase de type II, d'inhibition de la croissance cellulaire et d'induction de l'apoptose et qu'il est donc utilisable en tant qu'agent thérapeutique ou prophylactique contre divers cancers.
(JA)
 本発明者らは、中南米に生息するマメ科ジャケツイバラ属植物パウ・フェロの幹部に含まれる活性成分の分離を行い、これらの成分について、II型DNAトポイソメラーゼに対する阻害活性の検討を行った。その結果、パウ・フェロの抽出物は優れたII型DNAトポイソメラーゼ阻害作用、細胞増殖抑制作用、およびアポトーシス誘導作用を持ち、各種癌疾患の治療または予防剤として有用であることを見出した。
Also published as
Latest bibliographic data on file with the International Bureau