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Machine translation
1. (WO2007096743) SUBSTITUTED QUINAZOLINES AS PDE10 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/096743    International Application No.:    PCT/IB2007/000411
Publication Date: 30.08.2007 International Filing Date: 09.02.2007
Chapter 2 Demand Filed:    02.08.2007    
IPC:
C07D 471/04 (2006.01), C07D 471/14 (2006.01), A61K 31/437 (2006.01), A61K 31/4375 (2006.01), A61K 31/519 (2006.01), A61P 25/24 (2006.01), A61P 25/28 (2006.01)
Applicants: PFIZER PRODUCTS INC. [US/US]; Eastern Point Road, Groton, CT 06340 (US) (For All Designated States Except US).
ALLEN, Martin, Patrick [US/US]; (US) (For US Only).
CHAPPIE, Thomas, Allen [US/US]; (US) (For US Only).
HUMPHREY, John, Michael [US/US]; (US) (For US Only).
LIRAS, Spiros [GR/GR]; (US) (For US Only)
Inventors: ALLEN, Martin, Patrick; (US).
CHAPPIE, Thomas, Allen; (US).
HUMPHREY, John, Michael; (US).
LIRAS, Spiros; (US)
Agent: FULLER, Grover, F., Jr.; c/o DROUIN, Stéphane, Pfizer Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ (GB)
Priority Data:
60/776,112 23.02.2006 US
Title (EN) SUBSTITUTED QUINAZOLINES AS PDE10 INHIBITORS
(FR) QUINAZOLINES SUBSTITUÉES EN TANT QU'INHIBITEURS DE PDE10
Abstract: front page image
(EN)The invention pertains to substituted quinazoline compounds of structures (I) and (II) that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom. (I, II).
(FR)La présente invention concerne des quinazolines substituées qui jouent le rôle d'inhibiteurs efficaces de phosphodiestérase (PDE). La présente invention concerne également des composés qui sont des inhibiteurs sélectifs de la PDE-10. La présente invention concerne également des intermédiaires de synthèse de tels composés; des compositions pharmaceutiques comprenant de tels composés; et l'emploi de tels composés dans des méthodes de traitement de certains troubles du système nerveux central (SNC) ou d'autres troubles. La présente invention concerne de plus des méthodes de traitement de troubles neurodégénératifs et psychiatriques, par exemple la psychose et les troubles dont l'un des symptômes est une déficience cognitive.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)