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1. (WO2007096739) INTESTINAL ALPHA-GLUCOSIDASE INHIBITORS AND A PROCESS FOR THE ISOLATION AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/096739    International Application No.:    PCT/IB2007/000400
Publication Date: 30.08.2007 International Filing Date: 20.02.2007
Chapter 2 Demand Filed:    19.12.2007    
IPC:
A61K 36/185 (2006.01), A61K 31/352 (2006.01), A61P 3/04 (2006.01), A61P 3/10 (2006.01), A61K 31/70 (2006.01)
Applicants: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH [IN/IN]; Rafi Marg, New Delhi 110 001 (IN) (For All Designated States Except US).
RAO, Janaswamy, Madhusudana [IN/IN]; (IN) (For US Only).
KATRAGADDA, Suresh, Babu [IN/IN]; (IN) (For US Only).
TIWARI, Ashok, Kumar [IN/IN]; (IN) (For US Only).
TATIPAKA, Hari, Babu [IN/IN]; (IN) (For US Only).
PULLELA, Venkata, Srinivas [IN/IN]; (IN) (For US Only).
SURYADEVARA, Praveen, Kumar [IN/IN]; (IN) (For US Only).
SASTRY, Boggavarapu, Subrahmanya [IN/IN]; (IN) (For US Only).
ALI, Amtul, Zehra [IN/IN]; (IN) (For US Only).
YADAV, Jhillu, Singh [IN/IN]; (IN) (For US Only)
Inventors: RAO, Janaswamy, Madhusudana; (IN).
KATRAGADDA, Suresh, Babu; (IN).
TIWARI, Ashok, Kumar; (IN).
TATIPAKA, Hari, Babu; (IN).
PULLELA, Venkata, Srinivas; (IN).
SURYADEVARA, Praveen, Kumar; (IN).
SASTRY, Boggavarapu, Subrahmanya; (IN).
ALI, Amtul, Zehra; (IN).
YADAV, Jhillu, Singh; (IN)
Agent: BHATTACHARYYA, Goutam; K & S Partners, 84-C, C-6 Lane, Off Central Avenue, Sainik Farms, New Delhi 110 062 (IN)
Priority Data:
0477/DEL/2006 21.02.2006 IN
Title (EN) INTESTINAL ALPHA-GLUCOSIDASE INHIBITORS AND A PROCESS FOR THE ISOLATION AND USE THEREOF
(FR) INHIBITEURS DE L'ALPHA-GLUCOSIDASE INTESTINALE ET PROCÉDÉ POUR ISOLER ET UTILISER CEUX-CI
Abstract: front page image
(EN)This invention provides α-glucosidase inhibitors isolated from Oroxylum indicum an Indian medicinal plant. Particularly, this invention provides hexane and acetone fraction of Oroxylum indicum wherein the hexane fraction comprises α-glucosidase active compounds of oroxylin A, chrysin and baicalain and acetone fraction comprises the compounds of oroxylin A, chrysin, baicalain, methoxy chrysin and oroxyloside methyl ester. This invention also relates to a process for the isolation of α-glucosidase inhibitory active compounds from the above said hexane and acetone fraction of Oroxylum indicum. This invention also provides the use of potent intestinal α-glucosidase inhibitors as active ingredients that can be used in pharmaceuticals, food products, health foods and specialized health care foods as anti hyperglycemic agent for prevention and treatment of post prandial hyperglycemia, hyperglycemia and related conditions in diabetes mellitus, obesity and disease conditions requiring hyperglycemic control as well as inhibition of α-glucosidase activity.
(FR)La présente invention concerne des inhibiteurs de l'α-glucosidase isolés à partir de Oroxylum indicum, une plante médicinale indienne. En particulier, cette invention concerne des fractions extraites à l'hexane et à l'acétone de Oroxylum indicum, ladite fraction extraite à l'hexane comprenant des composés actifs d'α-glucosidase d'oroxyline A, de chrysine et de baicaline et ladite fraction extraite à l'acétone comprenant les composés d'oroxyline A, de chrysine, de baicaline, de méthoxychrysine et d'ester méthylique d'oroxyloside. Cette invention concerne également un procédé pour isoler des composés ayant une activité d'inhibition de l'α-glucosidase à partir desdites fractions ci-dessus extraites à l'hexane et à l'acétone de Oroxylum indicum. Cette invention concerne également l'utilisation d'inhibiteurs puissants de l'α-glucosidase intestinale en tant qu'ingrédients actifs qui peuvent être utilisés dans des produits pharmaceutiques, des produits alimentaires, des aliments diététiques et des aliments de soin de santé spécialisés en tant qu'agent de lutte contre l'hyperglycémie pour la prévention et le traitement de l'hyperglycémie postprandiale, de l'hyperglycémie et d'affections apparentées dans le diabète sucré, l'obésité et les maladies nécessitant la régulation de l'hyperglycémie ainsi que l'inhibition de l'activité de l'α-glucosidase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)