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1. WO2007096633 - INFECTIVITY ASSAY

Publication Number WO/2007/096633
Publication Date 30.08.2007
International Application No. PCT/GB2007/000630
International Filing Date 23.02.2007
Chapter 2 Demand Filed 19.12.2007
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 2800/2821
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
28Neurological disorders
2814Dementia; Cognitive disorders
2821Alzheimer
G01N 2800/2828
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
28Neurological disorders
2814Dementia; Cognitive disorders
2828Prion diseases
G01N 33/6896
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6893related to diseases not provided for elsewhere
6896Neurological disorders, e.g. Alzheimer's disease
Applicants
  • HEALTH PROTECTION AGENCY [GB]/[GB] (AllExceptUS)
  • HESP, Richard [GB]/[GB] (UsOnly)
  • SUTTON, J., Mark [GB]/[GB] (UsOnly)
  • ALEXANDER, Frances [GB]/[GB] (UsOnly)
  • KIRBY, Elizabeth [GB]/[GB] (UsOnly)
  • RAVEN, Neil [GB]/[GB] (UsOnly)
Inventors
  • HESP, Richard
  • SUTTON, J., Mark
  • ALEXANDER, Frances
  • KIRBY, Elizabeth
  • RAVEN, Neil
Agents
  • MACLEAN, Martin, Robert
Priority Data
0603775.824.02.2006GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INFECTIVITY ASSAY
(FR) DOSAGE D'INFECTIVITÉ
Abstract
(EN)
There is provided a method for infecting a target cell with a TSE agent, comprising: i) contacting said target cell with a membrane preparation, wherein the membrane preparation comprises the TSE agent and a donor membrane; and ii) infecting said target cell with the TSE agent. There is also provided a contiguous membrane, comprising a donor membrane and a membrane containing a TSE agent, wherein the TSE agent is selected from the group consisting of CJD, vCJD, familial CJD (eg. FFI or CSS), iatrogenic CJD, BSE, ovine BSE, and CWD.
(FR)
L'invention concerne une méthode pour infecter une cellule cible avec un agent TSE, qui consiste à : i) mettre ladite cellule cible en contact avec une préparation de membrane, ladite préparation de membrane comprenant l'agent TSE et une membrane donneuse ; et ii) infecter ladite cellule cible avec l'agent TSE. L'invention concerne aussi une membrane contiguë, comprenant une membrane donneuse et une membrane qui contient un agent TSE, ledit agent TSE étant sélectionné parmi le groupe qui comprend CJD, vCJD, CJD familial (par ex. : FFI ou CSS), CJD iatrogénique, BSE, BSE ovin et CWD.
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