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1. (WO2007096251) INHIBITORS OF CPT IN THE CENTRAL NERVOUS SYSTEM AS ANTIDIABETIC AND/OR ANTI-OBESITY DRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/096251    International Application No.:    PCT/EP2007/051197
Publication Date: 30.08.2007 International Filing Date: 08.02.2007
IPC:
C07D 211/14 (2006.01), C07D 295/08 (2006.01), C07D 295/12 (2006.01), A61K 31/455 (2006.01), A61K 31/4965 (2006.01), A61P 3/06 (2006.01)
Applicants: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. [IT/IT]; Viale Shakespeare, 47, I-00144 Roma (IT) (For All Designated States Except US).
TASSONI, Emanuela [IT/IT]; (IT) (For US Only).
GIANNESSI, Fabio [IT/IT]; (IT) (For US Only).
DELL' UOMO, Natalina [IT/IT]; (IT) (For US Only).
GALLO, Grazia [IT/IT]; (IT) (For US Only).
CONTI, Roberto [IT/IT]; (IT) (For US Only).
TINTI, Maria Ornella [IT/IT]; (IT) (For US Only)
Inventors: TASSONI, Emanuela; (IT).
GIANNESSI, Fabio; (IT).
DELL' UOMO, Natalina; (IT).
GALLO, Grazia; (IT).
CONTI, Roberto; (IT).
TINTI, Maria Ornella; (IT)
Priority Data:
RM2006A000090 22.02.2006 IT
Title (EN) INHIBITORS OF CPT IN THE CENTRAL NERVOUS SYSTEM AS ANTIDIABETIC AND/OR ANTI-OBESITY DRUGS
(FR) INHIBITEURS DE CPT DANS LE SYSTÈME NERVEUX CENTRAL EN TANT QUE MÉDICAMENTS ANTIDIABÉTIQUES ET/OU ANTI-OBÉSITÉ
Abstract: front page image
(EN)The invention relates to a new class of compounds with inhibitory action on carnitine palmitoyl transferase (CPT) in the central nervous system (SNC), derived from trimetazidine and perhexiline, preferentially selective for the hepatic form of CPT1 (CPT1L), pharmaceutical compounds which contain at least one new compound according to the invention, and their therapeutic use in the treatment and/or in the prevention of obesity, hyperglycaemia, diabetes and disorders associated with them, such as, for example, diabetic retinopathy, diabetic neuropathy and cardiovascular disorders. The compounds of the present invention are also used in the prevention and/or treatment of heart disorders such as CHF (congestive heart failure).
(FR)La présente invention concerne une nouvelle classe de composés à activité inhibitrice vis-à-vis de la carnitine palmitoyltransférase (CPT) dans le système nerveux central (SNC), lesdits composés étant dérivés de la trimétazidine et de la perhexiline, et étant de préférence sélectifs vis-à-vis de la forme hépatique de CPT1 (CPT1L). La présente invention concerne également les composés pharmaceutiques contenant au moins un nouveau composé selon l'invention, ainsi que leur utilisation thérapeutique dans le traitement prophylactique et/ou thérapeutique de l'obésité, de l'hyperglycémie, du diabète et des troubles associés, par exemple la rétinopathie diabétique, la neuropathie diabétique et les troubles cardio-vasculaires. Les composés selon la présente invention sont également employés dans le traitement prophylactique et/ou thérapeutique de troubles cardiaques tels que l'insuffisance cardiaque congestive (ICC).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)