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1. WO2007095867 - IMMUNOMODULATORY AND ANTI-TUMOUR PEPTIDES

Publication Number WO/2007/095867
Publication Date 30.08.2007
International Application No. PCT/CU2007/000006
International Filing Date 23.02.2007
IPC
C07K 14/435 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/43509
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
43509from crustaceans
Applicants
  • CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA [CU]/[CU] (AllExceptUS)
  • GUERRA VALLESPÍ, Maribel [CU]/[CU] (UsOnly)
  • TORRÉNS MADRAZO, Isis, del Carmen [CU]/[CU] (UsOnly)
  • REYES ACOSTA, Osvaldo [CU]/[CU] (UsOnly)
  • GARAY PÉREZ, Hilda, Elisa [CU]/[CU] (UsOnly)
  • GUILLÉN NIETO, Gerardo, Enrique [CU]/[CU] (UsOnly)
  • ACEVEDO CASTRO, Boris, Ernesto [CU]/[CU] (UsOnly)
  • UBIETA GÓMEZ, Raimundo [CU]/[CU] (UsOnly)
Inventors
  • GUERRA VALLESPÍ, Maribel
  • TORRÉNS MADRAZO, Isis, del Carmen
  • REYES ACOSTA, Osvaldo
  • GARAY PÉREZ, Hilda, Elisa
  • GUILLÉN NIETO, Gerardo, Enrique
  • ACEVEDO CASTRO, Boris, Ernesto
  • UBIETA GÓMEZ, Raimundo
Agents
  • VAZQUEZ CASTILLO, Mariela
Priority Data
2006-004724.02.2006CU
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) IMMUNOMODULATORY AND ANTI-TUMOUR PEPTIDES
(ES) PEPTIDOS CON CAPACIDAD ANTI-TUMORAL E INMUNOMODULADORA
(FR) PEPTIDES AVANT UNE PROPRIETE ANTI-TUMORALE ET IMMUNOMODULATRICE
Abstract
(EN)
The invention relates to the development of peptides originating from sequence HYRIKPTFRRLKWKKYKGKFW, into which amino acid substitutions have been introduced, which guarantee the dissociation of the lipopolysaccharide-binding capacity and potentiate the anti-tumour and immunomodulatory effect. Said peptides and combinations thereof can be used in the treatment of cancer, as well as in synergism with other standard therapies.
(ES)
La presente invención se relaciona con el desarrollo de péptidos provenientes de la secuencia HYRIKPTFRRLKWKKYKGKFW en la cual se han introducido sustituciones de animo ácidos que garantizan la disociación de la capacidad de unión al lipopolisacárido y potencian el efecto antitumoral e inmunomodulador. Estos péptidos o combinaciones de ellos son útiles para el tratamiento del cáncer, así como en sinergismo con las terapias convencionales.
(FR)
L'invention porte sur le développement de peptides issus de la séquence HYRIKPTFRRLKWKKYKGKFW, et dans laquelle on a introduit des substitutions d'acides aminés, qui assurent la dissociation de la capacité de liaison au lipopolysaccharide, et qui potentialisent l'effet anti-tumoral et immunomodulateur. Lesdits peptides et leurs combinaisons peuvent être utilisés dans le traitement du cancer, ainsi qu'en synergie avec les thérapies classiques.
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