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1. (WO2007095812) SUBSTITUTED [1,3,5] TRIAZINE COMPOUNDS, THEIR PROCESSES FOR PREPARATION AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/095812    International Application No.:    PCT/CN2006/003428
Publication Date: 30.08.2007 International Filing Date: 15.12.2006
IPC:
C07D 251/18 (2006.01), C07D 251/52 (2006.01), C07D 251/54 (2006.01), C07D 401/04 (2006.01), C07D 403/04 (2006.01), C07D 417/04 (2006.01), C07D 413/04 (2006.01), A61K 31/395 (2006.01), A61K 31/435 (2006.01), A61K 31/496 (2006.01), A61K 31/497 (2006.01), A61K 31/5377 (2006.01), A61K 31/5395 (2006.01), A61K 31/541 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; N?555 Zuchongzhi Road Z hangjiang Hi-tech Park P udong New District S hanghai 201203 (CN) (For All Designated States Except US).
LIU, Hong [CN/CN]; (CN) (For US Only).
JIANG, Hualiang [CN/CN]; (CN) (For US Only).
SHEN, Xu [CN/CN]; (CN) (For US Only).
DING, Jian [CN/CN]; (CN) (For US Only).
ZHU, Xingzu [CN/CN]; (CN) (For US Only).
LIN, Liping [CN/CN]; (CN) (For US Only).
ZHENG, Mingfang [CN/CN]; (CN) (For US Only).
ZHENG, Mingyue [CN/CN]; (CN) (For US Only).
ZHOU, Yu [CN/CN]; (CN) (For US Only).
JI, Xinquan [CN/CN]; (CN) (For US Only).
LUO, Haibin [CN/CN]; (CN) (For US Only).
LUO, Xiaomin [CN/CN]; (CN) (For US Only).
SHEN, Jianhua [CN/CN]; (CN) (For US Only).
CHEN, Kaixian [CN/CN]; (CN) (For US Only)
Inventors: LIU, Hong; (CN).
JIANG, Hualiang; (CN).
SHEN, Xu; (CN).
DING, Jian; (CN).
ZHU, Xingzu; (CN).
LIN, Liping; (CN).
ZHENG, Mingfang; (CN).
ZHENG, Mingyue; (CN).
ZHOU, Yu; (CN).
JI, Xinquan; (CN).
LUO, Haibin; (CN).
LUO, Xiaomin; (CN).
SHEN, Jianhua; (CN).
CHEN, Kaixian; (CN)
Agent: KINGSOUND & PARTNERS; 11/F, block B, kingsound International Center 116 Zizhuyuan Road Haidian District Beijing 100097 (CN)
Priority Data:
200610057786.6 27.02.2006 CN
Title (EN) SUBSTITUTED [1,3,5] TRIAZINE COMPOUNDS, THEIR PROCESSES FOR PREPARATION AND USES THEREOF
(FR) COMPOSÉS TRIAZINE [1,3,5] SUBSTITUÉS, PROCÉDÉS DE PRÉPARATION ET UTILISATIONS DE CEUX-CI
(ZH) 取代[1,3,5]三嗪类化合物及其制备方法和应用
Abstract: front page image
(EN)This invention discloses the substituted [1,3,5] triazine compounds of following formula, their pharmaceutically acceptable salts and solvates or hydrates, the pharmaceutical compositions containing the compounds and the uses thereof. The compositions of the present invention may be used for the prevention and/or treatment of inflammation diseases, which have good effect. The substituted [1,3,5] triazine compounds or their pharmaceutically acceptable salts show remarkable EGFR enzyme inhibitory activity and antitumor activity in a serious of selective tests of EGFR enzyme level and tumor cell level (human HT-29 and HCT-116). So The compositions of the present invention may be used for the prevention and/or treatment and/or aid treatment of tumor diseases.
(FR)L'invention concerne des composés triazine [1,3,5] substitués de formule suivante (I), leurs sels et solvates ou hydrates acceptables sur le plan pharmaceutique, des compositions pharmaceutiques les contenant et leurs utilisations. Les compositions de l'invention peuvent être utilisées pour la prévention et/ou le traitement de maladies inflammatoires, et produisent un effet bénéfique. Lesdits composés triazine [1,3,5] substitués ou leurs sels acceptables sur le plan pharmaceutique ont présenté une activité inhibitrice de l'enzyme EGFR et une activité antitumorale remarquables lors d'une série de tests sélectifs du niveau de l'enzyme EGFR et du niveau de cellule tumorale (HT-29 et HCT-116 humaines). Les compositions de l'invention peuvent ainsi être utilisées pour la prévention et/ou le traitement et/ou le traitement d'appoint de maladies tumorales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)