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Machine translation
1. (WO2007095760) CLEAVABLE CARNITINE COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/095760    International Application No.:    PCT/CA2007/000302
Publication Date: 30.08.2007 International Filing Date: 23.02.2007
IPC:
C07D 339/04 (2006.01), A61K 31/205 (2006.01), A61K 31/385 (2006.01), A61P 3/00 (2006.01), A61P 39/06 (2006.01), C07C 323/52 (2006.01)
Applicants: NOU LIFE SCIENCES, INC. [CA/CA]; 1500, 10180-101 Street, Edmonton, Alberta T5J 4K1 (CA) (For All Designated States Except US).
SINGH, Inder Pal [CA/CA]; (CA) (For US Only).
SINGH, Shradha [CA/CA]; (CA) (For US Only).
NOUJAIM, Antoine [CA/CA]; (CA) (For US Only).
HIRSCHE, Bruce D. [CA/CA]; (CA) (For US Only).
TAM, David S. [CA/CA]; (CA) (For US Only)
Inventors: SINGH, Inder Pal; (CA).
SINGH, Shradha; (CA).
NOUJAIM, Antoine; (CA).
HIRSCHE, Bruce D.; (CA).
TAM, David S.; (CA)
Agent: PARLEE MCLAWS LLP; 1500, 10180-101 Street, Edmonton, Alberta T5J 4K1 (CA)
Priority Data:
60/775,867 23.02.2006 US
Title (EN) CLEAVABLE CARNITINE COMPOUND
(FR) DÉRIVÉ CLIVABLE DE CARNITINE
Abstract: front page image
(EN)The invention includes novel compounds, including but not limited to formula A and formula B, and an improved delivery method. These compounds and methods are useful in preventing or treating diseases or conditions associated with or caused by the presence of free radicals, and are useful for increasing cellular metabolism while simultaneously alleviating the resultant increase in oxidative stress. Specifically, a carnitine is bound to a lipoic acid derivative or to dihydrolipoic acid or its derivatives using a hydrolysable linker to form a single compound.
(FR)La présente invention concerne de nouveaux composés, incluant sans y être limités, ceux qui sont représentés par les formules A et B, ainsi qu'une méthode de libération améliorée. Ces composés et méthodes peuvent être employés dans le traitement prophylactique ou thérapeutique de maladies ou d'états pathologiques liés ou provoqués par la présence de radicaux libres, ainsi que pour amplifier le métabolisme cellulaire tout en soulageant l'augmentation résultante de stress oxydant. De façon plus spécifique, une carnitine est liée à un dérivé d'acide lipoïque ou à l'acide dihydrolipoïque ou l'un de ses dérivés par le biais d'un groupement pontant hydrolysable, ce qui permet de former un composé unique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)