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Machine translation
1. (WO2007095753) 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/095753    International Application No.:    PCT/CA2007/000287
Publication Date: 30.08.2007 International Filing Date: 22.02.2007
IPC:
C07D 235/02 (2006.01), A61K 31/4184 (2006.01)
Applicants: MERCK FROSST CANADA LTD. [CA/CA]; 16711 Trans-Canada Highway, Kirkland, Québec H9H 3L1 (CA) (For All Designated States Except US).
CHAU, Anh [CA/CA]; (CA) (For US Only).
COTE, Bernard [CA/CA]; (CA) (For US Only).
DUCHARME, Yves [CA/CA]; (CA) (For US Only).
FRENETTE, Richard [CA/CA]; (CA) (For US Only).
FRIESEN, Richard [CA/CA]; (CA) (For US Only).
GAGNON, Marc [CA/CA]; (CA) (For US Only).
GIROUX, Andre [CA/CA]; (CA) (For US Only).
MARTINS, Evelyn [CA/CA]; (CA) (For US Only).
YU, Hongping [CA/CA]; (CA) (For US Only).
HAMEL, Pierre [CA/CA]; (CA) (For US Only)
Inventors: CHAU, Anh; (CA).
COTE, Bernard; (CA).
DUCHARME, Yves; (CA).
FRENETTE, Richard; (CA).
FRIESEN, Richard; (CA).
GAGNON, Marc; (CA).
GIROUX, Andre; (CA).
MARTINS, Evelyn; (CA).
YU, Hongping; (CA).
HAMEL, Pierre; (CA)
Agent: OGILVY RENAULT LLP/S.E.N.C.R.L., S.R.L.; Suite 1600, 1981 McGill College Avenue, Montréal, Québec H3A 2Y3 (CA)
Priority Data:
60/776,392 24.02.2006 US
60/796,803 02.05.2006 US
Title (EN) 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES
(FR) 1H-PHÉNANTHRO[9,10-D]IMIDAZOLES SUBSTITUÉS EN 2 PAR UN PHÉNYLE OU UN HÉTÉROCYCLE
Abstract: front page image
(EN)The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
(FR)La présente invention concerne les nouveaux composés de Formule (I) ou les sels de qualité pharmaceutique desdits composés. Lesdits composés sont des inhibiteurs de l'enzyme prostaglandine E synthétase microsomale 1 (mPGES-1) et peuvent donc être employés dans le traitement de douleurs et/ou d'inflammations dues à un grand nombre de maladies ou d'états pathologiques, tels que l'ostéoarthrose, la polyarthrite rhumatoïde et les douleurs aiguës ou chroniques. La présente invention concerne également des méthodes de traitement des maladies ou des états pathologiques dans lesquels intervient l'enzyme mPGES-1, ainsi que des compositions pharmaceutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)