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1. (WO2007095632) CRYSTALLINE FORMS OF (3R,4R)-4-AMINO-1-[[4-[(3-METHOXYPHENYL)AMINO]PYRROLO[2,1-F][1,2,4]TRIAZIN-5-YL]METHOL]PIPERIDIN-3-OL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/095632    International Application No.:    PCT/US2007/062276
Publication Date: 23.08.2007 International Filing Date: 16.02.2007
IPC:
C07D 487/04 (2006.01), A61K 31/53 (2006.01), A61P 35/00 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P.O. Box 4000, Route 206 and ProvinceLine Road, Princeton, NJ 08543-4000 (US) (For All Designated States Except US).
WEI, Chenkou [US/US]; (US) (For US Only).
NORRIS, Derek, J. [CA/US]; (US) (For US Only)
Inventors: WEI, Chenkou; (US).
NORRIS, Derek, J.; (US)
Agent: KORSEN, Elliott; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543-4000 (US)
Priority Data:
60/773,923 16.02.2006 US
Title (EN) CRYSTALLINE FORMS OF (3R,4R)-4-AMINO-1-[[4-[(3-METHOXYPHENYL)AMINO]PYRROLO[2,1-F][1,2,4]TRIAZIN-5-YL]METHOL]PIPERIDIN-3-OL
(FR) FORMES CRISTALLINES DE (3R,4R)-4-AMINO-1-[[4-[(3-METHOXYPHENYL)AMINO]PYRROLO[2,1-F][1,2,4]TRIAZIN-5-YL]METHOL]PIPERIDIN-3-OL
Abstract: front page image
(EN)Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol of the formula (I) are provided. Also provided is a pharmaceutical composition comprising one or more crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol, as well as a method of using one or more crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol in the treatment of cancer and other proliferative diseases.
(FR)L'invention concerne des formes cristallines de (3R,4R)-4-amino-1-[[4-[(3-méthoxyphényl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]méthyl]pipéridin-3-ol de formule (I). L'invention concerne également une composition pharmaceutique comprenant une ou plusieurs formes cristallines de (3R,4R)-4-amino-1-[[4-[(3-méthoxyphényl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]méthyl]pipéridin-3-ol, ainsi qu'un procédé d'utilisation d'une ou de plusieurs formes cristallines de (3R,4R)-4-amino-1-[[4-[(3-méthoxyphényl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]méthyl]pipéridin-3-ol pour le traitement du cancer et d'autres maladies prolifératives.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)