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1. (WO2007095561) INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/095561    International Application No.:    PCT/US2007/062106
Publication Date: 23.08.2007 International Filing Date: 14.02.2007
IPC:
C07D 209/42 (2006.01), C07D 401/04 (2006.01), C07D 405/06 (2006.01), C07D 405/12 (2006.01), C07D 405/14 (2006.01), C07D 409/04 (2006.01), C07D 409/06 (2006.01), A61K 31/404 (2006.01), A61P 27/00 (2006.01)
Applicants: ALLERGAN, INC. [US/US]; 2525 Dupont Drive, Irvine, CA 92612 (US) (For All Designated States Except US).
BEARD, Richard, L. [US/US]; (US) (For US Only).
DONELLO, John, E. [US/US]; (US) (For US Only).
YUAN, Haiqing [CN/US]; (US) (For US Only).
LIU, Xiaoxia [US/US]; (US) (For US Only).
DUONG, Tien [US/US]; (US) (For US Only).
COLON, Diana, F. [US/US]; (US) (For US Only).
HU, Yihui [US/US]; (US) (For US Only)
Inventors: BEARD, Richard, L.; (US).
DONELLO, John, E.; (US).
YUAN, Haiqing; (US).
LIU, Xiaoxia; (US).
DUONG, Tien; (US).
COLON, Diana, F.; (US).
HU, Yihui; (US)
Agent: BARAN, Robert, J.; C/o Allergan, Inc., 2525 Dupont Drive, Irvine, CA 92612 (US)
Priority Data:
60/774,102 15.02.2006 US
60/884,470 11.01.2007 US
Title (EN) INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY
(FR) COMPOSES AMIDE D'ACIDE INDOLE-3-CARBOXYLIQUE, ESTER, THIOAMIDE ET ESTER DE THIOL PORTEURS DE GROUPES ARYL OU HETEROARYL PRESENTANT UNE ACTIVITE BIOLOGIQUE ANTAGONISTE SUR LE RECEPTEUR SPHINGOSINE-1-PHOSPHATE (S1P)
Abstract: front page image
(EN)The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1 -phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, A, X, Z, R1, o, R3, R2 and p are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing.
(FR)La présente invention concerne des composés représentés par la formule I, chaque composé pouvant avoir une activité biologique agoniste et/ou antagoniste sur le récepteur sphingosine-1-phosphate, et dans laquelle les variables Y, R4, n, A, X, Z, R1, o, R3, R2 et p sont telles que définies dans la description. Ces composés servent à traiter une maladie ou un état sélectionné dans le groupe constitué par le glaucome, la kératoconjonctivite sèche, l'angiogenèse, les états et les maladies cardiovasculaires, et à soigner des plaies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)