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1. (WO2007095338) FUNCTIONAL ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/095338 International Application No.: PCT/US2007/004051
Publication Date: 23.08.2007 International Filing Date: 15.02.2007
IPC:
A61K 39/00 (2006.01) ,A61K 39/395 (2006.01) ,C12P 21/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
Applicants:
ZHU, Zhenping [CN/US]; US (UsOnly)
IMCLONE SYSTEMS INCORPORATED [US/US]; 180 Varick Street New York, NY 10014, US (AllExceptUS)
Inventors:
ZHU, Zhenping; US
Agent:
KAMAGE, Andrea, J. ; LERNER, DAVID, LITTENBERG, KRUMHOLZ & MENTLIK, LLP 600 South Avenue West Westfield, NJ 07090-1497, US
Priority Data:
60/773,99415.02.2006US
Title (EN) FUNCTIONAL ANTIBODIES
(FR) FORMULATION D'ANTICORPS
Abstract:
(EN) The invention is directed to novel antibodies, which comprise single domain binding sites. The antibodies can be bivalent or multivalent, and can be bispecific. The invention is further directed to monospecific and bispecific antibodies that bind to mPDGFRα. The antibodies can be administered alone or in combination with anti- angiogenic or anti-neoplastic drugs.
(FR) L'invention concerne de nouveaux anticorps qui comprennent des sites de liaison à domaine unique. Les anticorps peuvent être bivalents ou multivalents et ils peuvent être bispécifiques. L'invention concerne en outre des anticorps monospécifiques et bispécifiques qui se lient au mPDGFRα. Ces anticorps peuvent être administrés seuls ou en combinaison avec des médicaments anti-angiogènes ou anti-néoplasiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)