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Pub. No.:    WO/2007/095056    International Application No.:    PCT/US2007/003382
Publication Date: 23.08.2007 International Filing Date: 08.02.2007
A61B 5/00 (2006.01), A61M 37/00 (2006.01), A61N 1/30 (2006.01)
Applicants: GENZYME CORPORATION [US/US]; 15 Pleasant Street Connector, Framingham, MA 01701-9322 (US) (For All Designated States Except US).
DODGE, James [US/US]; (US) (For US Only).
PASSINI, Marco [US/US]; (US) (For US Only).
SHIHABUDDIN, Lamya [US/US]; (US) (For US Only).
CHENG, Seng [US/US]; (US) (For US Only)
Inventors: DODGE, James; (US).
PASSINI, Marco; (US).
CHENG, Seng; (US)
Agent: KAGAN, Sarah A.; BANNER & WITCOFF, LTD., Eleventh Floor, 1001 G Street, N.W., Washington, D.C. 20001-4597 (US)
Priority Data:
60/771,451 09.02.2006 US
Abstract: front page image
(EN)Neurological diseases, including lysosomal storage diseases, can be successfully treated using intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier. Similarly, diagnostic agents and anesthetic agents can be delivered to the brain in this manner. The administration can be performed slowly to achieve maximum effect. Such administration permits greater penetration of distal portions of the brain.
(FR)Des maladies neurologiques, y compris des maladies lysosomales, peuvent être traitées avec succès par administration intraventriculaire d'agents thérapeutiques afin d'éviter la barrière hématoméningée. De même, des agents diagnostiques et des agents anesthésiques peuvent être administrés au cerveau de cette manière. L'administration peut être réalisée lentement pour obtenir un effet maximum. Une telle administration permet une plus grande pénétration des portions distales du cerveau.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)