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1. (WO2007094330) PEPTIDE CAPABLE OF ACTIVATING BOMBESIN-LIKE PEPTIDE RECEPTOR AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/094330    International Application No.:    PCT/JP2007/052552
Publication Date: 23.08.2007 International Filing Date: 14.02.2007
IPC:
C12N 15/09 (2006.01), A61K 31/7088 (2006.01), A61K 38/00 (2006.01), A61K 48/00 (2006.01), A61P 3/04 (2006.01), A61P 43/00 (2006.01), C07K 7/06 (2006.01), C07K 16/18 (2006.01), C12N 1/15 (2006.01), C12N 1/19 (2006.01), C12N 1/21 (2006.01), C12N 5/10 (2006.01), C12P 21/02 (2006.01)
Applicants: National Institute of Advanced Industrial Science and Technology [JP/JP]; 3-1, Kasumigaseki 1-chome, Chiyoda-ku, Tokyo 1008921 (JP) (For All Designated States Except US).
SUWA, Makiko [JP/JP]; (JP) (For US Only).
HIROKAWA, Takatsugu [JP/JP]; (JP) (For US Only).
MUKAI, Hidehito [JP/JP]; (JP) (For US Only)
Inventors: SUWA, Makiko; (JP).
HIROKAWA, Takatsugu; (JP).
MUKAI, Hidehito; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
2006-038503 15.02.2006 JP
Title (EN) PEPTIDE CAPABLE OF ACTIVATING BOMBESIN-LIKE PEPTIDE RECEPTOR AND USE THEREOF
(FR) PEPTIDE CAPABLE D'ACTIVER UN RECEPTEUR POUR PEPTIDES ANALOGUES A LA BOMBESINE ET SON UTILISATION
(JA) ボンベシン様ペプチド受容体を活性化するペプチド、およびその利用
Abstract: front page image
(EN)The structures of a plurality of peptide ligands, each having a minimum activity unit which is believed to activate BRS-3, are predicted from the human genome sequence. Next, some peptides each having the minimum activity unit are chemically synthesized based on the predicted peptide structures, and the BRS-3 activation ability of the synthesized peptides are then examined. As a result, it is found that a peptide having the following amino acid sequence: Leu-Trp-Ala-Cys-Gly-Ser-Phe-Met (SEQ ID NO:3) can activate BRS-3 in a selective manner.
(FR)Selon la présente invention, les structures d'une pluralité de peptides ligands, possédant chacun une unité d'activité minimale censée activer le BRS-3, sont prévues à partir d'une séquence du génome humain. Puis, certains peptides présentant chacun l'unité d'activité minimale sont synthétisés chimiquement à l'aide des structures de peptides prévues et la capacité d'activation du BRS-3 par les peptides synthétisés est ensuite étudiée. Le résultat a montré qu'un peptide possédant la séquence d'acides aminés suivante, Leu-Trp-Ala-Cys-Gly-Ser-Phe-Met (SEQ ID N°3), peut activer le BRS-3 de manière sélective.
(JA) 本発明者らは、まず、ヒトゲノム配列からBRS-3を活性化すると考えられる最小活性単位を含む、複数のペプチド性リガンドの構造を予測した。次に、予測したペプチドの構造を基に、最小活性単位を含むいくつかのペプチドを化学合成し、これらのペプチドのBRS-3活性化能について検討を行った。その結果、アミノ酸配列Leu-Trp-Ala-Cys-Gly-Ser-Phe-Met(配列番号:3)で示されるペプチドが、BRS-3を選択的に活性化することを見出した。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)