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1. (WO2007093840) USE OF CELL-SPECIFIC CONJUGATES FOR TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2007/093840 International Application No.: PCT/IB2006/001488
Publication Date: 23.08.2007 International Filing Date: 15.02.2006
IPC:
A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
MERCEP, Mladen [HR/HR]; HR (UsOnly)
MESIC, Milan [HR/HR]; HR (UsOnly)
TOMASKOVIC, Linda [HR/HR]; HR (UsOnly)
MARKOVIC, Stribor [HR/HR]; HR (UsOnly)
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR/HR]; Prilaz Baruna Filipovica 29 Zagreb 10000, HR (AllExceptUS)
Inventors:
MERCEP, Mladen; HR
MESIC, Milan; HR
TOMASKOVIC, Linda; HR
MARKOVIC, Stribor; HR
Priority Data:
Title (EN) USE OF CELL-SPECIFIC CONJUGATES FOR TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT
(FR) UTILISATION DE CONJUGUÉS SPÉCIFIQUES DE CELLULE POUR TRAITER DES MALADIES INFLAMMATOIRES DES VOIES GASTRO-INTESTINALES
Abstract:
(EN) The present invention is directed to methods for the prevention and treatment of inflammatory diseases, disorders, and conditions of gastrointestinal tract by administering to a patient in need of such treatment, conjugate compounds of Formula (VII) having low oral- bioavailability, or pharmaceutically acceptable salts, prodrugs, or solvate thereof wherein M represents a macrolide subunit possessing the property of accumulation in inflammatory cells, T represents an anti-inflammatory subunit that can be a steroid or nonsteroid (nonsteroidal moiety) derived from a non-steroid drug with anti- inflammatory, analgesic and/or antipyretic activity (NSAID) and L represents a linker covalently linking M and T. The present disclosure is also directed to pharmaceutical compositions containing conjugate compounds of Formula (VII) having low oral-bioavailability.
(FR) La présente invention concerne des méthodes de prévention et de traitement de maladies, de troubles, et de pathologies inflammatoires des voies gastro-intestinales en administrant à un patient nécessitant un tel traitement, des composés conjugués de Formule VII de faible biodisponibilité orale ou des sels, promédicaments ou solutés de ceux-ci pharmaceutiquement acceptables, M représentant une sous-unité macrolide qui possède une propriété d'accumulation dans des cellules inflammatoires, T représentant une sous-unité anti-inflammatoire qui peut être un stéroïde ou un non stéroïde (groupement non stéroïdien) dérivé d'un médicament non stéroïdien à activité anti-inflammatoire, analgésique et/ou antipyrétique (AINS), et L représentant un lieur covalent entre M et T. La présente invention concerne aussi des compositions pharmaceutiques contenant des composés conjugués de Formule VII à faible biodisponibilité orale.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)