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1. (WO2007093635) PROTEASOM OR UPS INHIBITOR FOR TREATING INFECTIONS WITH INFLUENZA VIRUSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/093635    International Application No.:    PCT/EP2007/051510
Publication Date: 23.08.2007 International Filing Date: 16.02.2007
IPC:
A61P 31/16 (2006.01), A61K 31/165 (2006.01), A61K 31/336 (2006.01), A61P 31/12 (2006.01), A61K 31/00 (2006.01), A61K 45/06 (2006.01), A61K 31/69 (2006.01)
Applicants: VIROLOGIK GMBH [DE/DE]; Henkestrasse 91, 91052 Erlangen (DE) (For All Designated States Except US).
SCHUBERT, Ulrich [DE/DE]; (DE) (For US Only).
LUDWIG, Stephan [DE/DE]; (DE) (For US Only).
PLANZ, Oliver [DE/DE]; (DE) (For US Only)
Inventors: SCHUBERT, Ulrich; (DE).
LUDWIG, Stephan; (DE).
PLANZ, Oliver; (DE)
Agent: WEHLAN, Helmut; Wehlan & Wehlan, Patentanwaelte, Moellendorffstrasse 49, 10367 Berlin (DE)
Priority Data:
10 2006 008 321.0 17.02.2006 DE
Title (DE) PROTEASOM- ODER UPS-INHIBITOR ZUR BEHANDLUNG VON INFEKTIONEN MIT INFLUENZAVIREN
(EN) PROTEASOM OR UPS INHIBITOR FOR TREATING INFECTIONS WITH INFLUENZA VIRUSES
(FR) SUBSTANCES POUR TRAITER DES INFECTIONS PAR DES VIRUS GRIPPAUX
Abstract: front page image
(DE)Die Erfindung betrifft Mittel zur Prophylaxe und/oder Behandlung von Virus-Infektionen, insbesondere von Infektionen mit grippalen Infekten auslösenden Influenza Viren. Gegenstand der Erfindung sind Mittel, die als Wirkstoffe Inhibitoren des Ubiquitin-Proteasom-Systems, insbesondere Proteasominhibitoren, enthalten. Die vorliegende Erfindung betrifft des Weiteren die systemische als auch die topische, bevorzugt die aerogene Verabreichung von Proteasominhibitoren. Die erfindungsgemäße eingesetzte Wirksubstanz eines Proteasominhibitors kann mit mindestens einer weiteren antiviral wirksamen Substanz zur Prophylaxe und/oder Therapie von Influenzavirus-Infektionen eingesetzt werden.
(EN)The invention relates to compositions for the prophylaxis and/or treatment of viral infections, in particular of infections with influenza viruses which cause influenzal infections. The invention relates to compositions which comprise inhibitors of the ubiquitin-proteasome system, in particular proteasome inhibitors, as active ingredients. The present invention further relates to the systemic and topical, preferably the aerogenic administration of proteasome inhibitors. The active substance employed according to the invention as proteasome inhibitor can be employed with at least one further substance having antiviral activity for the prophylaxis and/or therapy of influenzavirus infections.
(FR)La présente invention concerne des substances pour prévenir et/ou traiter des infections virales, en particulier des infections par des virus grippaux qui déclenchent des infections grippales. L'invention a pour objet des substances qui contiennent comme principes actifs des inhibiteurs du système ubiquitine/protéasome, en particulier des inhibiteurs du protéasome. L'invention concerne aussi l'administration systémique, topique, de préférence aérogène d'inhibiteurs du protéasome. La substance active d'un inhibiteur de protéasome, employée selon l'invention, peut être utilisée avec au moins une autre substance à action anti-virale, pour prévenir et/ou traiter des infections par des virus grippaux.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)